NEJM
Aggiornamenti aggregati dai feed ufficiali del New England Journal of Medicine.
Sibeprenlimab in IgA Nephropathy — Final Phase 3 Trial Analysis — NEJM Nephrology
In this phase 3, double-blind, randomized trial involving patients with IgA nephropathy, sibeprenlimab stabilized the eGFR slope over 24 months, consistent with a reduced risk of kidney-function decline.Fonte: NEJM Nephrology — Categoria: medical_journals
Atacicept in IgA Nephropathy — Phase 3 Trial Final Efficacy Analysis — NEJM Nephrology
In patients with IgA nephropathy, atacicept, a human TACI–Fc fusion protein that modulates B-cell activity, slowed and stabilized the decline in the eGFR as compared with placebo.Fonte: NEJM Nephrology — Categoria: medical_journals
Sibeprenlimab in IgA Nephropathy — Final Phase 3 Trial Analysis — NEJM Allergy-Immunology
In this phase 3, double-blind, randomized trial involving patients with IgA nephropathy, sibeprenlimab stabilized the eGFR slope over 24 months, consistent with a reduced risk of kidney-function decline.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Atacicept in IgA Nephropathy — Phase 3 Trial Final Efficacy Analysis — NEJM Allergy-Immunology
In patients with IgA nephropathy, atacicept, a human TACI–Fc fusion protein that modulates B-cell activity, slowed and stabilized the decline in the eGFR as compared with placebo.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Sibeprenlimab in IgA Nephropathy — Final Phase 3 Trial Analysis — NEJM Clinical Medicine
In this phase 3, double-blind, randomized trial involving patients with IgA nephropathy, sibeprenlimab stabilized the eGFR slope over 24 months, consistent with a reduced risk of kidney-function decline.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Atacicept in IgA Nephropathy — Phase 3 Trial Final Efficacy Analysis — NEJM Clinical Medicine
In patients with IgA nephropathy, atacicept, a human TACI–Fc fusion protein that modulates B-cell activity, slowed and stabilized the decline in the eGFR as compared with placebo.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Ianalumab for the Treatment of Patients with Sjögren’s Disease — NEJM Rheumatology
In two trials involving patients with active Sjögren’s disease, decreases in disease activity at 48 weeks were greater with monthly ianalumab than with placebo, but differences in response rates and symptom scores were not significant.Fonte: NEJM Rheumatology — Categoria: medical_journals
Ianalumab in Sjögren’s Disease — A First Step — NEJM Rheumatology
Sjögren’s disease has long frustrated clinicians, trialists, and — most important — patients for whom effective treatments remain elusive. Glandular dysfunction causes dryness; fatigue and pain add substantially to daily burden; and systemic manifestations can affect major organs. These dimensions of disease do not nec…
Ianalumab for the Treatment of Patients with Sjögren’s Disease — NEJM Pulmonary-critical-care
In two trials involving patients with active Sjögren’s disease, decreases in disease activity at 48 weeks were greater with monthly ianalumab than with placebo, but differences in response rates and symptom scores were not significant.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy — NEJM Pulmonary-critical-care
Among patients with relapsed small-cell lung cancer after chemotherapy, treatment with tambotatug pelitecan led to longer survival than treatment with topotecan, with fewer adverse events of grade 3 or higher.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Ianalumab in Sjögren’s Disease — A First Step — NEJM Pulmonary-critical-care
Sjögren’s disease has long frustrated clinicians, trialists, and — most important — patients for whom effective treatments remain elusive. Glandular dysfunction causes dryness; fatigue and pain add substantially to daily burden; and systemic manifestations can affect major organs. These dimensions of disease do not nec…
What I See before Anyone Speaks — NEJM Pulmonary-critical-care
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Tuberculous Empyema Resulting in Pseudochylothorax — NEJM Pulmonary-critical-care
A man presented with a 3-month history of cough, dyspnea, and fatigue. CT showed a pleural effusion with thickening and enhancement of the parietal and visceral pleura. Examination of pleural fluid showed cholesterol crystals.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Pediatrics
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Pediatrics — Categoria: medical_journals
Reengineering Coagulation with a Bispecific Antibody — NEJM Hematology-oncology
Kunihiro Hattori, Tomoyuki Igawa, and Takehisa Kitazawa, who developed a prophylactic therapy for hemophilia A, have received the 2026 Lasker–DeBakey Clinical Medical Research Award.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
In Vivo Aquaporin-1 Circular RNA Therapy for Radiation-Induced Xerostomia — NEJM Hematology-oncology
In a phase 1 study, RXRG001, a circular RNA encoding aquaporin-1, was administered to six patients with radiation-induced xerostomia. Measures of salivary flow improved, and adverse events were of grade 1 or 2 and transient.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Case 30-2026: A 52-Year-Old Man with Vision Loss in the Left Eye — NEJM Hematology-oncology
A 52-year-old man with metastatic small-cell lung cancer was evaluated in the ophthalmology clinic because of vision loss in the left eye. A blood cytomegalovirus DNA viral load was 348 IU per milliliter. A diagnosis was made.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Helicobacter pylori Infection — Advances, Challenges, and the Road Ahead — NEJM Infectious diseases
The discovery of H. pylori has advanced the prevention and treatment of gastritis, peptic ulcers, and gastric cancer. Progress has been made in the research of H. pylori infection. These advances are discussed in this review.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis — NEJM Infectious diseases
Among adults with endocarditis caused by S. aureus, E. faecalis, or streptococcus species, tailored-duration antibiotic therapy led to 13 more days alive without antibiotics than standard therapy, but with a higher incidence of relapse.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Spinal Tuberculosis — NEJM Infectious diseases
A 36-year-old woman presented with a 6-year history of gradually worsening low back pain and intermittent night sweats. On examination, she had a sharp, kyphotic angulation of the lower spine.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Infective Endocarditis — When Is Enough Enough? — NEJM Infectious diseases
Infective endocarditis has traditionally been treated with intravenous antimicrobial agents for a defined number of weeks.1 Clinicians have been understandably reluctant to use oral antimicrobial therapy or truncate the duration of treatment owing to one universally feared and potentially lethal complication: relapse o…
Helicobacter pylori Infection — Advances, Challenges, and the Road Ahead — NEJM Gastroenterology
The discovery of H. pylori has advanced the prevention and treatment of gastritis, peptic ulcers, and gastric cancer. Progress has been made in the research of H. pylori infection. These advances are discussed in this review.Fonte: NEJM Gastroenterology — Categoria: medical_journals
In Vivo Aquaporin-1 Circular RNA Therapy for Radiation-Induced Xerostomia — NEJM Genetics
In a phase 1 study, RXRG001, a circular RNA encoding aquaporin-1, was administered to six patients with radiation-induced xerostomia. Measures of salivary flow improved, and adverse events were of grade 1 or 2 and transient.Fonte: NEJM Genetics — Categoria: medical_journals
Conducting Research with Involuntarily Hospitalized Patients — Ethical, Legal, and Regulatory Considerations — NEJM Health policy
Studies of suicidality and other acute psychiatric conditions may require participation of involuntarily hospitalized patients, but guidelines are needed to ensure that such research is ethical.Fonte: NEJM Health policy — Categoria: medical_journals
Helicobacter pylori Infection — Advances, Challenges, and the Road Ahead — NEJM Hematology-oncology
The discovery of H. pylori has advanced the prevention and treatment of gastritis, peptic ulcers, and gastric cancer. Progress has been made in the research of H. pylori infection. These advances are discussed in this review.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Why Shared-Savings ACOs Have Failed to Deliver for Primary Care — NEJM Health policy
Accountable care organizations gave primary care physicians responsibility for managing overall patient care and achieving quality targets — without improving the PCP experience as promised.Fonte: NEJM Health policy — Categoria: medical_journals
Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy — NEJM Hematology-oncology
Among patients with relapsed small-cell lung cancer after chemotherapy, treatment with tambotatug pelitecan led to longer survival than treatment with topotecan, with fewer adverse events of grade 3 or higher.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Neurology-neurosurgery
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Clinical Trial Prediction Markets — Information, at What Cost? — NEJM Health policy
Prediction-market platforms are introducing betting on clinical trials. Although these markets could produce useful signals about the likelihood of a trial’s success, they could also compromise trial integrity.Fonte: NEJM Health policy — Categoria: medical_journals
Spinal Tuberculosis — NEJM Neurology-neurosurgery
A 36-year-old woman presented with a 6-year history of gradually worsening low back pain and intermittent night sweats. On examination, she had a sharp, kyphotic angulation of the lower spine.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Community Engagement Requirements in Medicaid — Law as a Determinant of Health — NEJM Health policy
New Medicaid eligibility rules will burden both beneficiaries and physicians, threaten funding for health care institutions and clinicians, and leave more U.S. residents without insurance coverage.Fonte: NEJM Health policy — Categoria: medical_journals
Tuberculous Empyema Resulting in Pseudochylothorax — NEJM Infectious diseases
A man presented with a 3-month history of cough, dyspnea, and fatigue. CT showed a pleural effusion with thickening and enhancement of the parietal and visceral pleura. Examination of pleural fluid showed cholesterol crystals.Fonte: NEJM Infectious diseases — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Geriatrics-Aging
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Case 30-2026: A 52-Year-Old Man with Vision Loss in the Left Eye — NEJM Infectious diseases
A 52-year-old man with metastatic small-cell lung cancer was evaluated in the ophthalmology clinic because of vision loss in the left eye. A blood cytomegalovirus DNA viral load was 348 IU per milliliter. A diagnosis was made.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Reengineering Coagulation with a Bispecific Antibody — NEJM Genetics
Kunihiro Hattori, Tomoyuki Igawa, and Takehisa Kitazawa, who developed a prophylactic therapy for hemophilia A, have received the 2026 Lasker–DeBakey Clinical Medical Research Award.Fonte: NEJM Genetics — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Infectious diseases
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Infectious diseases — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Health policy
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Health policy — Categoria: medical_journals
Conducting Research with Involuntarily Hospitalized Patients — Ethical, Legal, and Regulatory Considerations — NEJM Clinical Medicine
Studies of suicidality and other acute psychiatric conditions may require participation of involuntarily hospitalized patients, but guidelines are needed to ensure that such research is ethical.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event — NEJM Clinical Medicine
Adding milvexian to standard antiplatelet therapy after an acute coronary syndrome event did not lower the risk of a composite of cardiovascular death, MI, or ischemic stroke but did not increase intracranial or fatal bleeding.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event — NEJM Emergency Medicine
Adding milvexian to standard antiplatelet therapy after an acute coronary syndrome event did not lower the risk of a composite of cardiovascular death, MI, or ischemic stroke but did not increase intracranial or fatal bleeding.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Community Engagement Requirements in Medicaid — Law as a Determinant of Health — NEJM Clinical Medicine
New Medicaid eligibility rules will burden both beneficiaries and physicians, threaten funding for health care institutions and clinicians, and leave more U.S. residents without insurance coverage.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event — NEJM Cardiology
Adding milvexian to standard antiplatelet therapy after an acute coronary syndrome event did not lower the risk of a composite of cardiovascular death, MI, or ischemic stroke but did not increase intracranial or fatal bleeding.Fonte: NEJM Cardiology — Categoria: medical_journals
Ianalumab for the Treatment of Patients with Sjögren’s Disease — NEJM Allergy-Immunology
In two trials involving patients with active Sjögren’s disease, decreases in disease activity at 48 weeks were greater with monthly ianalumab than with placebo, but differences in response rates and symptom scores were not significant.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Case 30-2026: A 52-Year-Old Man with Vision Loss in the Left Eye — NEJM Clinical Medicine
A 52-year-old man with metastatic small-cell lung cancer was evaluated in the ophthalmology clinic because of vision loss in the left eye. A blood cytomegalovirus DNA viral load was 348 IU per milliliter. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Role for Factor XIa Inhibitors after an Acute Coronary Syndrome Event — NEJM Cardiology
Despite the receipt of guideline-directed medical therapies and potent antiplatelet agents, patients who have had an acute coronary syndrome event are at increased risk for a recurrent ischemic event.1,2 Considerable interest has been focused on the addition of anticoagulation to further mitigate ischemic risk in such …
Tuberculous Empyema Resulting in Pseudochylothorax — NEJM Clinical Medicine
A man presented with a 3-month history of cough, dyspnea, and fatigue. CT showed a pleural effusion with thickening and enhancement of the parietal and visceral pleura. Examination of pleural fluid showed cholesterol crystals.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Role for Factor XIa Inhibitors after an Acute Coronary Syndrome Event — NEJM Clinical Medicine
Despite the receipt of guideline-directed medical therapies and potent antiplatelet agents, patients who have had an acute coronary syndrome event are at increased risk for a recurrent ischemic event.1,2 Considerable interest has been focused on the addition of anticoagulation to further mitigate ischemic risk in such …
Why Shared-Savings ACOs Have Failed to Deliver for Primary Care — NEJM Clinical Medicine
Accountable care organizations gave primary care physicians responsibility for managing overall patient care and achieving quality targets — without improving the PCP experience as promised.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Ianalumab for the Treatment of Patients with Sjögren’s Disease — NEJM Dermatology
In two trials involving patients with active Sjögren’s disease, decreases in disease activity at 48 weeks were greater with monthly ianalumab than with placebo, but differences in response rates and symptom scores were not significant.Fonte: NEJM Dermatology — Categoria: medical_journals
Ianalumab in Sjögren’s Disease — A First Step — NEJM Dermatology
Sjögren’s disease has long frustrated clinicians, trialists, and — most important — patients for whom effective treatments remain elusive. Glandular dysfunction causes dryness; fatigue and pain add substantially to daily burden; and systemic manifestations can affect major organs. These dimensions of disease do not nec…
Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis — NEJM Clinical Medicine
Among adults with endocarditis caused by S. aureus, E. faecalis, or streptococcus species, tailored-duration antibiotic therapy led to 13 more days alive without antibiotics than standard therapy, but with a higher incidence of relapse.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Clinical Medicine
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Ianalumab for the Treatment of Patients with Sjögren’s Disease — NEJM Clinical Medicine
In two trials involving patients with active Sjögren’s disease, decreases in disease activity at 48 weeks were greater with monthly ianalumab than with placebo, but differences in response rates and symptom scores were not significant.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Ianalumab in Sjögren’s Disease — A First Step — NEJM Clinical Medicine
Sjögren’s disease has long frustrated clinicians, trialists, and — most important — patients for whom effective treatments remain elusive. Glandular dysfunction causes dryness; fatigue and pain add substantially to daily burden; and systemic manifestations can affect major organs. These dimensions of disease do not nec…
Infective Endocarditis — When Is Enough Enough? — NEJM Cardiology
Infective endocarditis has traditionally been treated with intravenous antimicrobial agents for a defined number of weeks.1 Clinicians have been understandably reluctant to use oral antimicrobial therapy or truncate the duration of treatment owing to one universally feared and potentially lethal complication: relapse o…
Spinal Tuberculosis — NEJM Clinical Medicine
A 36-year-old woman presented with a 6-year history of gradually worsening low back pain and intermittent night sweats. On examination, she had a sharp, kyphotic angulation of the lower spine.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis — NEJM Cardiology
Among adults with endocarditis caused by S. aureus, E. faecalis, or streptococcus species, tailored-duration antibiotic therapy led to 13 more days alive without antibiotics than standard therapy, but with a higher incidence of relapse.Fonte: NEJM Cardiology — Categoria: medical_journals
Infective Endocarditis — When Is Enough Enough? — NEJM Clinical Medicine
Infective endocarditis has traditionally been treated with intravenous antimicrobial agents for a defined number of weeks.1 Clinicians have been understandably reluctant to use oral antimicrobial therapy or truncate the duration of treatment owing to one universally feared and potentially lethal complication: relapse o…
Helicobacter pylori Infection — Advances, Challenges, and the Road Ahead — NEJM Allergy-Immunology
The discovery of H. pylori has advanced the prevention and treatment of gastritis, peptic ulcers, and gastric cancer. Progress has been made in the research of H. pylori infection. These advances are discussed in this review.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Role for Factor XIa Inhibitors after an Acute Coronary Syndrome Event — NEJM Emergency Medicine
Despite the receipt of guideline-directed medical therapies and potent antiplatelet agents, patients who have had an acute coronary syndrome event are at increased risk for a recurrent ischemic event.1,2 Considerable interest has been focused on the addition of anticoagulation to further mitigate ischemic risk in such …
Ianalumab in Sjögren’s Disease — A First Step — NEJM Allergy-Immunology
Sjögren’s disease has long frustrated clinicians, trialists, and — most important — patients for whom effective treatments remain elusive. Glandular dysfunction causes dryness; fatigue and pain add substantially to daily burden; and systemic manifestations can affect major organs. These dimensions of disease do not nec…
Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea — NEJM Pulmonary-critical-care
In two trials involving participants with OSA and obesity or overweight with or without type 2 diabetes, treatment with retatrutide was found to result in greater decreases in the apnea–hypopnea index than placebo.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea — NEJM Geriatrics-Aging
In two trials involving participants with OSA and obesity or overweight with or without type 2 diabetes, treatment with retatrutide was found to result in greater decreases in the apnea–hypopnea index than placebo.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea — NEJM Clinical Medicine
In two trials involving participants with OSA and obesity or overweight with or without type 2 diabetes, treatment with retatrutide was found to result in greater decreases in the apnea–hypopnea index than placebo.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea — NEJM Endocrinology
In two trials involving participants with OSA and obesity or overweight with or without type 2 diabetes, treatment with retatrutide was found to result in greater decreases in the apnea–hypopnea index than placebo.Fonte: NEJM Endocrinology — Categoria: medical_journals
Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea — NEJM Gastroenterology
In two trials involving participants with OSA and obesity or overweight with or without type 2 diabetes, treatment with retatrutide was found to result in greater decreases in the apnea–hypopnea index than placebo.Fonte: NEJM Gastroenterology — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Pulmonary-critical-care
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Spinal Tuberculosis — NEJM Neurology-neurosurgery
A 36-year-old woman presented with a 6-year history of gradually worsening low back pain and intermittent night sweats. On examination, she had a sharp, kyphotic angulation of the lower spine.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Neurology-neurosurgery
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Pediatrics
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Pediatrics — Categoria: medical_journals
Community Engagement Requirements in Medicaid — Law as a Determinant of Health — NEJM Health policy
New Medicaid eligibility rules will burden both beneficiaries and physicians, threaten funding for health care institutions and clinicians, and leave more U.S. residents without insurance coverage.Fonte: NEJM Health policy — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Health policy
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Health policy — Categoria: medical_journals
Why Shared-Savings ACOs Have Failed to Deliver for Primary Care — NEJM Health policy
Accountable care organizations gave primary care physicians responsibility for managing overall patient care and achieving quality targets — without improving the PCP experience as promised.Fonte: NEJM Health policy — Categoria: medical_journals
Spinal Tuberculosis — NEJM Infectious diseases
A 36-year-old woman presented with a 6-year history of gradually worsening low back pain and intermittent night sweats. On examination, she had a sharp, kyphotic angulation of the lower spine.Fonte: NEJM Infectious diseases — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Infectious diseases
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Infectious diseases — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Geriatrics-Aging
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Community Engagement Requirements in Medicaid — Law as a Determinant of Health — NEJM Clinical Medicine
New Medicaid eligibility rules will burden both beneficiaries and physicians, threaten funding for health care institutions and clinicians, and leave more U.S. residents without insurance coverage.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Spinal Tuberculosis — NEJM Clinical Medicine
A 36-year-old woman presented with a 6-year history of gradually worsening low back pain and intermittent night sweats. On examination, she had a sharp, kyphotic angulation of the lower spine.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
What I See before Anyone Speaks — NEJM Clinical Medicine
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Why Shared-Savings ACOs Have Failed to Deliver for Primary Care — NEJM Clinical Medicine
Accountable care organizations gave primary care physicians responsibility for managing overall patient care and achieving quality targets — without improving the PCP experience as promised.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Alkaptonuria — NEJM Rheumatology
A 64-year-old woman presented with progressive stooped posture, low back pain, and difficulty walking. Examination showed black scleral pigmentation, and a urine sample turned black after standing overnight.Fonte: NEJM Rheumatology — Categoria: medical_journals
Case 29-2026: A 39-Year-Old Man with Abdominal Pain, Foot Drop, and a Spinal Mass — NEJM Surgery
A 39-year-old man, who was an Iraq War veteran with exposure to burn pits, was admitted to the hospital with hypertension, abdominal pain, and foot drop. Imaging showed a thoracic spinal mass. A diagnosis was made.Fonte: NEJM Surgery — Categoria: public_health
Not Available in Your Country — NEJM Surgery
Reflexively reaching for his phone to seek the answer to a medical student’s question, a physician educator finds that a widely used medical AI agent has been banned in his country.Fonte: NEJM Surgery — Categoria: public_health
Case 29-2026: A 39-Year-Old Man with Abdominal Pain, Foot Drop, and a Spinal Mass — NEJM Neurology-neurosurgery
A 39-year-old man, who was an Iraq War veteran with exposure to burn pits, was admitted to the hospital with hypertension, abdominal pain, and foot drop. Imaging showed a thoracic spinal mass. A diagnosis was made.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Integration-Associated Paraspinal Neoplasm after AAV Gene Therapy — NEJM Neurology-neurosurgery
The authors report AAV integration in a paraspinal neoplasm after gene therapy. The integrated sequence retained a CAG promoter–enhancer and activated a developmental transcription factor.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Obstetrics-gynecology
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Adult Attention Deficit–Hyperactivity Disorder — NEJM Pediatrics
This review summarizes the assessment and treatment of adult attention deficit–hyperactivity disorder, with an emphasis on common psychiatric and medical coexisting conditions and combined pharmacologic and psychosocial care.Fonte: NEJM Pediatrics — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Pediatrics
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Pediatrics — Categoria: medical_journals
Integration-Associated Paraspinal Neoplasm after AAV Gene Therapy — NEJM Pediatrics
The authors report AAV integration in a paraspinal neoplasm after gene therapy. The integrated sequence retained a CAG promoter–enhancer and activated a developmental transcription factor.Fonte: NEJM Pediatrics — Categoria: medical_journals
Adult Attention Deficit–Hyperactivity Disorder — NEJM Neurology-neurosurgery
This review summarizes the assessment and treatment of adult attention deficit–hyperactivity disorder, with an emphasis on common psychiatric and medical coexisting conditions and combined pharmacologic and psychosocial care.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Long-Acting HIV Therapy in African Adults with Adherence Challenges — NEJM Infectious diseases
Full adherence to daily antiretroviral therapy for HIV can be challenging. In this phase 3b trial in Kenya, South Africa, and Uganda, a long-acting ART regimen was noninferior to daily ART use.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Health-Related Social Needs among Older Adults — Addressing Mismeasurement — NEJM Geriatrics-Aging
Integration of screening for health-related social needs into clinical care represents an important advance. But most screening tools haven’t been developed or validated with older adults in mind.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes — NEJM Endocrinology
Among adults with type 2 diabetes not treated with insulin in primary care settings, continuous glucose monitoring led to greater reductions in glycated hemoglobin and a lower risk of hyperglycemia than usual care.Fonte: NEJM Endocrinology — Categoria: medical_journals
Flushing in Carcinoid Syndrome — NEJM Endocrinology
A 44-year-old man was admitted for the management of carcinoid syndrome, which had been diagnosed 4 years earlier. On examination, mottled, violaceous, blanchable flushing was seen across the face and torso.Fonte: NEJM Endocrinology — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Genetics
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Genetics — Categoria: medical_journals
Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes — NEJM Gastroenterology
Among adults with type 2 diabetes not treated with insulin in primary care settings, continuous glucose monitoring led to greater reductions in glycated hemoglobin and a lower risk of hyperglycemia than usual care.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Lonvoguran Ziclumeran — In Vivo CRISPR Gene Editing in Hereditary Angioedema — NEJM Hematology-oncology
In a phase 3, randomized trial of lonvo-z, an in vivo gene-editing therapy, patients with hereditary angioedema who received the drug had a significantly lower attack rate than those who received placebo.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Case 29-2026: A 39-Year-Old Man with Abdominal Pain, Foot Drop, and a Spinal Mass — NEJM Endocrinology
A 39-year-old man, who was an Iraq War veteran with exposure to burn pits, was admitted to the hospital with hypertension, abdominal pain, and foot drop. Imaging showed a thoracic spinal mass. A diagnosis was made.Fonte: NEJM Endocrinology — Categoria: medical_journals
Flushing in Carcinoid Syndrome — NEJM Hematology-oncology
A 44-year-old man was admitted for the management of carcinoid syndrome, which had been diagnosed 4 years earlier. On examination, mottled, violaceous, blanchable flushing was seen across the face and torso.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Case 29-2026: A 39-Year-Old Man with Abdominal Pain, Foot Drop, and a Spinal Mass — NEJM Hematology-oncology
A 39-year-old man, who was an Iraq War veteran with exposure to burn pits, was admitted to the hospital with hypertension, abdominal pain, and foot drop. Imaging showed a thoracic spinal mass. A diagnosis was made.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Adapting to Genomic Medicine — NEJM Hematology-oncology
Hereditary angioedema is a disorder characterized by unpredictable, transient episodes of swelling and pain of various body parts. It can be life-threatening if the airway is involved. Current therapies include several different products that are administered prophylactically or at the onset of symptoms, and the prophy…
IARC Perspective on Lung Cancer Screening — NEJM Hematology-oncology
The 21st volume of the IARC Handbooks summarizes and evaluates evidence for the benefits and harms of lung cancer screening with low-dose CT or chest radiography and assesses tools and strategies to improve screening.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Chemotherapy-free Treatment of Ph-Positive ALL — NEJM Hematology-oncology
It would be rare for anyone who has undergone intensive, multicycle, multiagent chemotherapy followed by allogeneic hematopoietic stem-cell transplantation to agree with Nietzsche’s personal view that “Out of life’s school of war, what does not kill me, makes me stronger.” Even though our past approaches to treating pa…
Firearm-Related Discussions as an Age-Friendly Intervention — NEJM Geriatrics-Aging
Older adults are vulnerable to firearm-related harms. Medicare’s annual wellness visit presents an opportunity to engage older adults and their families or caregivers in conversations about firearms.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Ponatinib–Blinatumomab or Imatinib–Chemotherapy for Adult Ph-Positive ALL — NEJM Hematology-oncology
In a trial involving adults with Ph-positive acute lymphoblastic leukemia, 24-month event-free survival was 86% with the TKI–immunotherapy combination ponatinib–blinatumomab and 67% with imatinib plus chemotherapy.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Integration-Associated Paraspinal Neoplasm after AAV Gene Therapy — NEJM Genetics
The authors report AAV integration in a paraspinal neoplasm after gene therapy. The integrated sequence retained a CAG promoter–enhancer and activated a developmental transcription factor.Fonte: NEJM Genetics — Categoria: medical_journals
Chemotherapy-free Treatment of Ph-Positive ALL — NEJM Health policy
It would be rare for anyone who has undergone intensive, multicycle, multiagent chemotherapy followed by allogeneic hematopoietic stem-cell transplantation to agree with Nietzsche’s personal view that “Out of life’s school of war, what does not kill me, makes me stronger.” Even though our past approaches to treating pa…
Adapting to Genomic Medicine — NEJM Genetics
Hereditary angioedema is a disorder characterized by unpredictable, transient episodes of swelling and pain of various body parts. It can be life-threatening if the airway is involved. Current therapies include several different products that are administered prophylactically or at the onset of symptoms, and the prophy…
Health-Related Social Needs among Older Adults — Addressing Mismeasurement — NEJM Health policy
Integration of screening for health-related social needs into clinical care represents an important advance. But most screening tools haven’t been developed or validated with older adults in mind.Fonte: NEJM Health policy — Categoria: medical_journals
Lonvoguran Ziclumeran — In Vivo CRISPR Gene Editing in Hereditary Angioedema — NEJM Genetics
In a phase 3, randomized trial of lonvo-z, an in vivo gene-editing therapy, patients with hereditary angioedema who received the drug had a significantly lower attack rate than those who received placebo.Fonte: NEJM Genetics — Categoria: medical_journals
Not Available in Your Country — NEJM Health policy
Reflexively reaching for his phone to seek the answer to a medical student’s question, a physician educator finds that a widely used medical AI agent has been banned in his country.Fonte: NEJM Health policy — Categoria: medical_journals
Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis — NEJM Gastroenterology
In a phase 2 trial of once-daily oral icotrokinra for moderately to severely active ulcerative colitis, a clinical response at week 12 was more common with icotrokinra at each of three tested doses than with placebo.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Health policy
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Health policy — Categoria: medical_journals
Alkaptonuria — NEJM Endocrinology
A 64-year-old woman presented with progressive stooped posture, low back pain, and difficulty walking. Examination showed black scleral pigmentation, and a urine sample turned black after standing overnight.Fonte: NEJM Endocrinology — Categoria: medical_journals
Firearm-Related Discussions as an Age-Friendly Intervention — NEJM Health policy
Older adults are vulnerable to firearm-related harms. Medicare’s annual wellness visit presents an opportunity to engage older adults and their families or caregivers in conversations about firearms.Fonte: NEJM Health policy — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Endocrinology
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Endocrinology — Categoria: medical_journals
Once-Weekly Mosnodenvir as Dengue Prophylaxis in a Human Infection Model — NEJM Infectious diseases
An antiviral therapy has not been approved for dengue. In this report, mosnodenvir, a small-molecule antiviral, was shown to be protective in a human challenge model of dengue, and a weekly regimen provided adequate blood levels.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Alkaptonuria — NEJM Genetics
A 64-year-old woman presented with progressive stooped posture, low back pain, and difficulty walking. Examination showed black scleral pigmentation, and a urine sample turned black after standing overnight.Fonte: NEJM Genetics — Categoria: medical_journals
Adult Attention Deficit–Hyperactivity Disorder — NEJM Clinical Medicine
This review summarizes the assessment and treatment of adult attention deficit–hyperactivity disorder, with an emphasis on common psychiatric and medical coexisting conditions and combined pharmacologic and psychosocial care.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Firearm-Related Discussions as an Age-Friendly Intervention — NEJM Clinical Medicine
Older adults are vulnerable to firearm-related harms. Medicare’s annual wellness visit presents an opportunity to engage older adults and their families or caregivers in conversations about firearms.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Case 29-2026: A 39-Year-Old Man with Abdominal Pain, Foot Drop, and a Spinal Mass — NEJM Clinical Medicine
A 39-year-old man, who was an Iraq War veteran with exposure to burn pits, was admitted to the hospital with hypertension, abdominal pain, and foot drop. Imaging showed a thoracic spinal mass. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Health-Related Social Needs among Older Adults — Addressing Mismeasurement — NEJM Clinical Medicine
Integration of screening for health-related social needs into clinical care represents an important advance. But most screening tools haven’t been developed or validated with older adults in mind.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Not Available in Your Country — NEJM Clinical Medicine
Reflexively reaching for his phone to seek the answer to a medical student’s question, a physician educator finds that a widely used medical AI agent has been banned in his country.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Flushing in Carcinoid Syndrome — NEJM Clinical Medicine
A 44-year-old man was admitted for the management of carcinoid syndrome, which had been diagnosed 4 years earlier. On examination, mottled, violaceous, blanchable flushing was seen across the face and torso.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Alkaptonuria — NEJM Clinical Medicine
A 64-year-old woman presented with progressive stooped posture, low back pain, and difficulty walking. Examination showed black scleral pigmentation, and a urine sample turned black after standing overnight.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes — NEJM Clinical Medicine
Among adults with type 2 diabetes not treated with insulin in primary care settings, continuous glucose monitoring led to greater reductions in glycated hemoglobin and a lower risk of hyperglycemia than usual care.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis — NEJM Clinical Medicine
In a phase 2 trial of once-daily oral icotrokinra for moderately to severely active ulcerative colitis, a clinical response at week 12 was more common with icotrokinra at each of three tested doses than with placebo.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Adapting to Genomic Medicine — NEJM Allergy-Immunology
Hereditary angioedema is a disorder characterized by unpredictable, transient episodes of swelling and pain of various body parts. It can be life-threatening if the airway is involved. Current therapies include several different products that are administered prophylactically or at the onset of symptoms, and the prophy…
Alkaptonuria — NEJM Dermatology
A 64-year-old woman presented with progressive stooped posture, low back pain, and difficulty walking. Examination showed black scleral pigmentation, and a urine sample turned black after standing overnight.Fonte: NEJM Dermatology — Categoria: medical_journals
Flushing in Carcinoid Syndrome — NEJM Dermatology
A 44-year-old man was admitted for the management of carcinoid syndrome, which had been diagnosed 4 years earlier. On examination, mottled, violaceous, blanchable flushing was seen across the face and torso.Fonte: NEJM Dermatology — Categoria: medical_journals
Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis — NEJM Allergy-Immunology
In a phase 2 trial of once-daily oral icotrokinra for moderately to severely active ulcerative colitis, a clinical response at week 12 was more common with icotrokinra at each of three tested doses than with placebo.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Lonvoguran Ziclumeran — In Vivo CRISPR Gene Editing in Hereditary Angioedema — NEJM Allergy-Immunology
In a phase 3, randomized trial of lonvo-z, an in vivo gene-editing therapy, patients with hereditary angioedema who received the drug had a significantly lower attack rate than those who received placebo.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury — NEJM Pulmonary-critical-care
An open-label, randomized, noninferiority trial showed that intermittent hemodialysis was not noninferior to continuous renal-replacement therapy in critically ill adults with acute kidney injury.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Continuous or Intermittent Renal-Replacement Therapy — What Is the Question? — NEJM Pulmonary-critical-care
Acute kidney injury is a common complication in critically ill patients and is associated with substantial morbidity and mortality. In the absence of effective pharmacotherapy, care is primarily supportive, with reliance on renal-replacement therapy until kidney function recovers. Although more than eight decades have …
Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury — NEJM Nephrology
An open-label, randomized, noninferiority trial showed that intermittent hemodialysis was not noninferior to continuous renal-replacement therapy in critically ill adults with acute kidney injury.Fonte: NEJM Nephrology — Categoria: medical_journals
Continuous or Intermittent Renal-Replacement Therapy — What Is the Question? — NEJM Nephrology
Acute kidney injury is a common complication in critically ill patients and is associated with substantial morbidity and mortality. In the absence of effective pharmacotherapy, care is primarily supportive, with reliance on renal-replacement therapy until kidney function recovers. Although more than eight decades have …
Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury — NEJM Emergency Medicine
An open-label, randomized, noninferiority trial showed that intermittent hemodialysis was not noninferior to continuous renal-replacement therapy in critically ill adults with acute kidney injury.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Continuous or Intermittent Renal-Replacement Therapy — What Is the Question? — NEJM Emergency Medicine
Acute kidney injury is a common complication in critically ill patients and is associated with substantial morbidity and mortality. In the absence of effective pharmacotherapy, care is primarily supportive, with reliance on renal-replacement therapy until kidney function recovers. Although more than eight decades have …
Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury — NEJM Clinical Medicine
An open-label, randomized, noninferiority trial showed that intermittent hemodialysis was not noninferior to continuous renal-replacement therapy in critically ill adults with acute kidney injury.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury — NEJM Cardiology
An open-label, randomized, noninferiority trial showed that intermittent hemodialysis was not noninferior to continuous renal-replacement therapy in critically ill adults with acute kidney injury.Fonte: NEJM Cardiology — Categoria: medical_journals
Continuous or Intermittent Renal-Replacement Therapy — What Is the Question? — NEJM Clinical Medicine
Acute kidney injury is a common complication in critically ill patients and is associated with substantial morbidity and mortality. In the absence of effective pharmacotherapy, care is primarily supportive, with reliance on renal-replacement therapy until kidney function recovers. Although more than eight decades have …
Not Available in Your Country — NEJM Surgery
Reflexively reaching for his phone to seek the answer to a medical student’s question, a physician educator finds that a widely used medical AI agent has been banned in his country.Fonte: NEJM Surgery — Categoria: public_health
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Pediatrics
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Pediatrics — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Obstetrics-gynecology
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Flushing in Carcinoid Syndrome — NEJM Endocrinology
A 44-year-old man was admitted for the management of carcinoid syndrome, which had been diagnosed 4 years earlier. On examination, mottled, violaceous, blanchable flushing was seen across the face and torso.Fonte: NEJM Endocrinology — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Genetics
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Genetics — Categoria: medical_journals
Firearm-Related Discussions as an Age-Friendly Intervention — NEJM Geriatrics-Aging
Older adults are vulnerable to firearm-related harms. Medicare’s annual wellness visit presents an opportunity to engage older adults and their families or caregivers in conversations about firearms.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Firearm-Related Discussions as an Age-Friendly Intervention — NEJM Health policy
Older adults are vulnerable to firearm-related harms. Medicare’s annual wellness visit presents an opportunity to engage older adults and their families or caregivers in conversations about firearms.Fonte: NEJM Health policy — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Health policy
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Health policy — Categoria: medical_journals
Not Available in Your Country — NEJM Health policy
Reflexively reaching for his phone to seek the answer to a medical student’s question, a physician educator finds that a widely used medical AI agent has been banned in his country.Fonte: NEJM Health policy — Categoria: medical_journals
Health-Related Social Needs among Older Adults — Addressing Mismeasurement — NEJM Health policy
Integration of screening for health-related social needs into clinical care represents an important advance. But most screening tools haven’t been developed or validated with older adults in mind.Fonte: NEJM Health policy — Categoria: medical_journals
Flushing in Carcinoid Syndrome — NEJM Hematology-oncology
A 44-year-old man was admitted for the management of carcinoid syndrome, which had been diagnosed 4 years earlier. On examination, mottled, violaceous, blanchable flushing was seen across the face and torso.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Who Counts as Infertile? A Missed Opportunity for Inclusion — NEJM Endocrinology
The World Health Organization recently issued its first global guidelines on the prevention, diagnosis, and treatment of infertility, but they pertain only to heterosexual couples.Fonte: NEJM Endocrinology — Categoria: medical_journals
Health-Related Social Needs among Older Adults — Addressing Mismeasurement — NEJM Geriatrics-Aging
Integration of screening for health-related social needs into clinical care represents an important advance. But most screening tools haven’t been developed or validated with older adults in mind.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Not Available in Your Country — NEJM Clinical Medicine
Reflexively reaching for his phone to seek the answer to a medical student’s question, a physician educator finds that a widely used medical AI agent has been banned in his country.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Firearm-Related Discussions as an Age-Friendly Intervention — NEJM Clinical Medicine
Older adults are vulnerable to firearm-related harms. Medicare’s annual wellness visit presents an opportunity to engage older adults and their families or caregivers in conversations about firearms.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Health-Related Social Needs among Older Adults — Addressing Mismeasurement — NEJM Clinical Medicine
Integration of screening for health-related social needs into clinical care represents an important advance. But most screening tools haven’t been developed or validated with older adults in mind.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Flushing in Carcinoid Syndrome — NEJM Dermatology
A 44-year-old man was admitted for the management of carcinoid syndrome, which had been diagnosed 4 years earlier. On examination, mottled, violaceous, blanchable flushing was seen across the face and torso.Fonte: NEJM Dermatology — Categoria: medical_journals
Flushing in Carcinoid Syndrome — NEJM Clinical Medicine
A 44-year-old man was admitted for the management of carcinoid syndrome, which had been diagnosed 4 years earlier. On examination, mottled, violaceous, blanchable flushing was seen across the face and torso.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia — NEJM Rheumatology
A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made.Fonte: NEJM Rheumatology — Categoria: medical_journals
Pediatric Heart Transplantation with Donation after Circulatory Death — NEJM Surgery
In five pediatric heart transplantations, a rapid-recovery technique involving oxygenated preservation enabled the use of donated hearts without reanimation. All recipients had normal biventricular function by day 7.Fonte: NEJM Surgery — Categoria: public_health
Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia — NEJM Pediatrics
A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made.Fonte: NEJM Pediatrics — Categoria: medical_journals
Menkes Disease — NEJM Pediatrics
A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries.Fonte: NEJM Pediatrics — Categoria: medical_journals
Pediatric Heart Transplantation with Donation after Circulatory Death — NEJM Pediatrics
In five pediatric heart transplantations, a rapid-recovery technique involving oxygenated preservation enabled the use of donated hearts without reanimation. All recipients had normal biventricular function by day 7.Fonte: NEJM Pediatrics — Categoria: medical_journals
Vasopressors or Fluids in Early Septic Shock — NEJM Pulmonary-critical-care
Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
More Than One Way to Save a Life in Septic Shock — NEJM Pulmonary-critical-care
Septic shock — the dysregulated response to infection that leads to end-organ hypoperfusion — remains a worldwide threat to patient’s lives and ability to thrive.1 There is consensus that excellent care for patients with septic shock involves early source control to limit the dysregulated “friendly fire” response in...…
Menkes Disease — NEJM Neurology-neurosurgery
A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Advances in Systemic Treatment of Breast Cancer — NEJM Genetics
This review summarizes advances in therapy, including approval or expanded use of targeted agents, improved outcomes with antibody–drug conjugates and immunotherapy, and growing reliance on molecular profiling.Fonte: NEJM Genetics — Categoria: medical_journals
A Step in the Search for the Elusive Holy Grail of Early Detection of Cancer — NEJM Genetics
The diagnosis of cancer at earlier stages is generally associated with improved survival. Detecting circulating tumor–derived cell-free DNA (cfDNA) is an established method of monitoring the response to therapy for many cancer types, particularly hematopoietic and metastatic cancers — which leads to the question of whe…
Reproducibility in Biomedical Science — From Repetition to Corroboration — NEJM Health policy
Biomedical research encompasses diverse scientific activities with distinct sources of variation, attainable precision, and standards of inference, as this functional typology of reproducibility clarifies.Fonte: NEJM Health policy — Categoria: medical_journals
Beyond Percentage of Weight Lost — Protecting Participants in Obesity Trials — NEJM Health policy
The efficacy and popularity of GLP-1 agents have sparked a race to develop increasingly potent therapies. But protections for people enrolled in trials of investigational products may be inadequate.Fonte: NEJM Health policy — Categoria: medical_journals
A Guide for the Perplexed Physician — NEJM Health policy
As access to medical knowledge is democratized, the specialist’s position atop the medical hierarchy grows shaky. With integration and synthesis more precious than ever, the generalist deserves reappraisal.Fonte: NEJM Health policy — Categoria: medical_journals
Clinical Trial Prediction Markets — Information, at What Cost? — NEJM Health policy
Prediction-market platforms are introducing betting on clinical trials. Although these markets could produce useful signals about the likelihood of a trial’s success, they could also compromise trial integrity.Fonte: NEJM Health policy — Categoria: medical_journals
Advances in Systemic Treatment of Breast Cancer — NEJM Hematology-oncology
This review summarizes advances in therapy, including approval or expanded use of targeted agents, improved outcomes with antibody–drug conjugates and immunotherapy, and growing reliance on molecular profiling.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
A Step in the Search for the Elusive Holy Grail of Early Detection of Cancer — NEJM Hematology-oncology
The diagnosis of cancer at earlier stages is generally associated with improved survival. Detecting circulating tumor–derived cell-free DNA (cfDNA) is an established method of monitoring the response to therapy for many cancer types, particularly hematopoietic and metastatic cancers — which leads to the question of whe…
Optogenetic Therapy for Restoring Aspects of Visual Function — NEJM Genetics
In this study, the safety of ganglion cell–directed optogenetic therapy was evaluated in 10 participants with blindness due to advanced retinitis pigmentosa.Fonte: NEJM Genetics — Categoria: medical_journals
Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia — NEJM Hematology-oncology
A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Science behind the Study: Optogenetics in Sight — NEJM Neurology-neurosurgery
The author describes the science behind a study of intravitreal delivery of an AAV vector encoding a light-gated ion channel in 10 blind patients with advanced retinitis pigmentosa.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis — NEJM Hematology-oncology
In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Optogenetic Therapy for Restoring Aspects of Visual Function — NEJM Neurology-neurosurgery
In this study, the safety of ganglion cell–directed optogenetic therapy was evaluated in 10 participants with blindness due to advanced retinitis pigmentosa.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Hantavirus — Lessons Learned about Security and Solidarity — NEJM Health policy
Pedro Sánchez and Tedros Adhanom Ghebreyesus reflect on the management of Andes hantavirus and the way in which careful, coordinated outbreak response can limit risk without undermining dignity.Fonte: NEJM Health policy — Categoria: medical_journals
Hantavirus — Lessons Learned about Security and Solidarity — NEJM Infectious diseases
Pedro Sánchez and Tedros Adhanom Ghebreyesus reflect on the management of Andes hantavirus and the way in which careful, coordinated outbreak response can limit risk without undermining dignity.Fonte: NEJM Infectious diseases — Categoria: medical_journals
More Than One Way to Save a Life in Septic Shock — NEJM Health policy
Septic shock — the dysregulated response to infection that leads to end-organ hypoperfusion — remains a worldwide threat to patient’s lives and ability to thrive.1 There is consensus that excellent care for patients with septic shock involves early source control to limit the dysregulated “friendly fire” response in...…
Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia — NEJM Infectious diseases
A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Grief as a Vector for Disease — Tradition and Public Health in Ebola Outbreaks — NEJM Health policy
When public health measures conflict with cultural, relational, and emotional practices surrounding severe illness and death, they may lead to uprisings that increase the risk of infection spread.Fonte: NEJM Health policy — Categoria: medical_journals
More Than One Way to Save a Life in Septic Shock — NEJM Infectious diseases
Septic shock — the dysregulated response to infection that leads to end-organ hypoperfusion — remains a worldwide threat to patient’s lives and ability to thrive.1 There is consensus that excellent care for patients with septic shock involves early source control to limit the dysregulated “friendly fire” response in...…
Menkes Disease — NEJM Genetics
A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries.Fonte: NEJM Genetics — Categoria: medical_journals
Grief as a Vector for Disease — Tradition and Public Health in Ebola Outbreaks — NEJM Infectious diseases
When public health measures conflict with cultural, relational, and emotional practices surrounding severe illness and death, they may lead to uprisings that increase the risk of infection spread.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Science behind the Study: Optogenetics in Sight — NEJM Genetics
The author describes the science behind a study of intravitreal delivery of an AAV vector encoding a light-gated ion channel in 10 blind patients with advanced retinitis pigmentosa.Fonte: NEJM Genetics — Categoria: medical_journals
Syphilitic Chancre on the Nipple — NEJM Infectious diseases
A 35-year-old woman presented with a 20-day history of a nipple ulcer. On examination, there was ulceration, crusting, and a yellowish exudate on the right nipple.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis — NEJM Genetics
In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone.Fonte: NEJM Genetics — Categoria: medical_journals
Vasopressors or Fluids in Early Septic Shock — NEJM Infectious diseases
Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Syphilitic Chancre on the Nipple — NEJM Obstetrics-gynecology
A 35-year-old woman presented with a 20-day history of a nipple ulcer. On examination, there was ulceration, crusting, and a yellowish exudate on the right nipple.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Syphilitic Chancre on the Nipple — NEJM Clinical Medicine
A 35-year-old woman presented with a 20-day history of a nipple ulcer. On examination, there was ulceration, crusting, and a yellowish exudate on the right nipple.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Reproducibility in Biomedical Science — From Repetition to Corroboration — NEJM Clinical Medicine
Biomedical research encompasses diverse scientific activities with distinct sources of variation, attainable precision, and standards of inference, as this functional typology of reproducibility clarifies.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
More Than One Way to Save a Life in Septic Shock — NEJM Clinical Medicine
Septic shock — the dysregulated response to infection that leads to end-organ hypoperfusion — remains a worldwide threat to patient’s lives and ability to thrive.1 There is consensus that excellent care for patients with septic shock involves early source control to limit the dysregulated “friendly fire” response in...…
Grief as a Vector for Disease — Tradition and Public Health in Ebola Outbreaks — NEJM Clinical Medicine
When public health measures conflict with cultural, relational, and emotional practices surrounding severe illness and death, they may lead to uprisings that increase the risk of infection spread.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Transcatheter Tricuspid-Valve Intervention for Severe Tricuspid Regurgitation — NEJM Cardiology
The care of patients with valvular heart disease has been revolutionized by three key advances in the field: technological innovation of transcatheter therapies combined with the audacity to try new procedures; a heart team that includes interventional cardiologists, cardiac surgeons, imaging specialists, and, when nee…
Beyond Percentage of Weight Lost — Protecting Participants in Obesity Trials — NEJM Endocrinology
The efficacy and popularity of GLP-1 agents have sparked a race to develop increasingly potent therapies. But protections for people enrolled in trials of investigational products may be inadequate.Fonte: NEJM Endocrinology — Categoria: medical_journals
Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia — NEJM Allergy-Immunology
A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Tricuspid-Valve Intervention in Heart Failure — NEJM Clinical Medicine
In patients with severe tricuspid regurgitation and heart failure, transcatheter tricuspid-valve repair plus medical therapy was superior to medical therapy alone in reducing hospitalizations for heart failure and deaths.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Pediatric Heart Transplantation with Donation after Circulatory Death — NEJM Clinical Medicine
In five pediatric heart transplantations, a rapid-recovery technique involving oxygenated preservation enabled the use of donated hearts without reanimation. All recipients had normal biventricular function by day 7.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
A Guide for the Perplexed Physician — NEJM Clinical Medicine
As access to medical knowledge is democratized, the specialist’s position atop the medical hierarchy grows shaky. With integration and synthesis more precious than ever, the generalist deserves reappraisal.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Syphilitic Chancre on the Nipple — NEJM Dermatology
A 35-year-old woman presented with a 20-day history of a nipple ulcer. On examination, there was ulceration, crusting, and a yellowish exudate on the right nipple.Fonte: NEJM Dermatology — Categoria: medical_journals
Vasopressors or Fluids in Early Septic Shock — NEJM Emergency Medicine
Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
More Than One Way to Save a Life in Septic Shock — NEJM Emergency Medicine
Septic shock — the dysregulated response to infection that leads to end-organ hypoperfusion — remains a worldwide threat to patient’s lives and ability to thrive.1 There is consensus that excellent care for patients with septic shock involves early source control to limit the dysregulated “friendly fire” response in...…
Vasopressors or Fluids in Early Septic Shock — NEJM Clinical Medicine
Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Menkes Disease — NEJM Clinical Medicine
A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis — NEJM Clinical Medicine
In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
A Step in the Search for the Elusive Holy Grail of Early Detection of Cancer — NEJM Clinical Medicine
The diagnosis of cancer at earlier stages is generally associated with improved survival. Detecting circulating tumor–derived cell-free DNA (cfDNA) is an established method of monitoring the response to therapy for many cancer types, particularly hematopoietic and metastatic cancers — which leads to the question of whe…
Pediatric Heart Transplantation with Donation after Circulatory Death — NEJM Cardiology
In five pediatric heart transplantations, a rapid-recovery technique involving oxygenated preservation enabled the use of donated hearts without reanimation. All recipients had normal biventricular function by day 7.Fonte: NEJM Cardiology — Categoria: medical_journals
Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia — NEJM Clinical Medicine
A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Tricuspid-Valve Intervention in Heart Failure — NEJM Cardiology
In patients with severe tricuspid regurgitation and heart failure, transcatheter tricuspid-valve repair plus medical therapy was superior to medical therapy alone in reducing hospitalizations for heart failure and deaths.Fonte: NEJM Cardiology — Categoria: medical_journals
Beyond Percentage of Weight Lost — Protecting Participants in Obesity Trials — NEJM Gastroenterology
The efficacy and popularity of GLP-1 agents have sparked a race to develop increasingly potent therapies. But protections for people enrolled in trials of investigational products may be inadequate.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Transcatheter Tricuspid-Valve Intervention for Severe Tricuspid Regurgitation — NEJM Clinical Medicine
The care of patients with valvular heart disease has been revolutionized by three key advances in the field: technological innovation of transcatheter therapies combined with the audacity to try new procedures; a heart team that includes interventional cardiologists, cardiac surgeons, imaging specialists, and, when nee…
Menkes Disease — NEJM Neurology-neurosurgery
A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Menkes Disease — NEJM Pediatrics
A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries.Fonte: NEJM Pediatrics — Categoria: medical_journals
Grief as a Vector for Disease — Tradition and Public Health in Ebola Outbreaks — NEJM Health policy
When public health measures conflict with cultural, relational, and emotional practices surrounding severe illness and death, they may lead to uprisings that increase the risk of infection spread.Fonte: NEJM Health policy — Categoria: medical_journals
Menkes Disease — NEJM Genetics
A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries.Fonte: NEJM Genetics — Categoria: medical_journals
Beyond Percentage of Weight Lost — Protecting Participants in Obesity Trials — NEJM Health policy
The efficacy and popularity of GLP-1 agents have sparked a race to develop increasingly potent therapies. But protections for people enrolled in trials of investigational products may be inadequate.Fonte: NEJM Health policy — Categoria: medical_journals
A Guide for the Perplexed Physician — NEJM Health policy
As access to medical knowledge is democratized, the specialist’s position atop the medical hierarchy grows shaky. With integration and synthesis more precious than ever, the generalist deserves reappraisal.Fonte: NEJM Health policy — Categoria: medical_journals
Hantavirus — Lessons Learned about Security and Solidarity — NEJM Health policy
Pedro Sánchez and Tedros Adhanom Ghebreyesus reflect on the management of Andes hantavirus and the way in which careful, coordinated outbreak response can limit risk without undermining dignity.Fonte: NEJM Health policy — Categoria: medical_journals
Grief as a Vector for Disease — Tradition and Public Health in Ebola Outbreaks — NEJM Infectious diseases
When public health measures conflict with cultural, relational, and emotional practices surrounding severe illness and death, they may lead to uprisings that increase the risk of infection spread.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Hantavirus — Lessons Learned about Security and Solidarity — NEJM Infectious diseases
Pedro Sánchez and Tedros Adhanom Ghebreyesus reflect on the management of Andes hantavirus and the way in which careful, coordinated outbreak response can limit risk without undermining dignity.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Beyond Percentage of Weight Lost — Protecting Participants in Obesity Trials — NEJM Endocrinology
The efficacy and popularity of GLP-1 agents have sparked a race to develop increasingly potent therapies. But protections for people enrolled in trials of investigational products may be inadequate.Fonte: NEJM Endocrinology — Categoria: medical_journals
Beyond Percentage of Weight Lost — Protecting Participants in Obesity Trials — NEJM Gastroenterology
The efficacy and popularity of GLP-1 agents have sparked a race to develop increasingly potent therapies. But protections for people enrolled in trials of investigational products may be inadequate.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Menkes Disease — NEJM Clinical Medicine
A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
A Guide for the Perplexed Physician — NEJM Clinical Medicine
As access to medical knowledge is democratized, the specialist’s position atop the medical hierarchy grows shaky. With integration and synthesis more precious than ever, the generalist deserves reappraisal.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Grief as a Vector for Disease — Tradition and Public Health in Ebola Outbreaks — NEJM Clinical Medicine
When public health measures conflict with cultural, relational, and emotional practices surrounding severe illness and death, they may lead to uprisings that increase the risk of infection spread.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes — NEJM Endocrinology
In this phase 3, double-blind, placebo-controlled trial involving adults with obesity and type 2 diabetes, the investigational glucagon receptor–GLP-1 receptor dual agonist survodutide led to significant weight reduction.Fonte: NEJM Endocrinology — Categoria: medical_journals
Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes — NEJM Gastroenterology
In this phase 3, double-blind, placebo-controlled trial involving adults with obesity and type 2 diabetes, the investigational glucagon receptor–GLP-1 receptor dual agonist survodutide led to significant weight reduction.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes — NEJM Clinical Medicine
In this phase 3, double-blind, placebo-controlled trial involving adults with obesity and type 2 diabetes, the investigational glucagon receptor–GLP-1 receptor dual agonist survodutide led to significant weight reduction.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
The Mayor — NEJM Surgery
When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.Fonte: NEJM Surgery — Categoria: public_health
Thyroglossal Duct Cyst — NEJM Surgery
A 6-year-old boy presented with an asymptomatic lump on the neck. Physical examination showed a nontender, midline mass in the anterior neck; ultrasonography showed a well-defined, hypoechoic mass and normal thyroid gland.Fonte: NEJM Surgery — Categoria: public_health
Bilateral Pacing Neuromuscular Prosthesis for Laryngeal Paralysis — NEJM Surgery
In four patients with bilateral vocal-fold paralysis, bilateral neuromuscular laryngeal pacing was found to restore vocal-fold abduction, increase inspiratory flow, and preserve voice and swallowing function.Fonte: NEJM Surgery — Categoria: public_health
Serotonin Syndrome — NEJM Pulmonary-critical-care
A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video).Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Bilateral Pacing Neuromuscular Prosthesis for Laryngeal Paralysis — NEJM Pulmonary-critical-care
In four patients with bilateral vocal-fold paralysis, bilateral neuromuscular laryngeal pacing was found to restore vocal-fold abduction, increase inspiratory flow, and preserve voice and swallowing function.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Obexelimab for the Treatment of IgG4-Related Disease — NEJM Rheumatology
In a phase 3 trial, obexelimab led to a lower risk of disease flares than placebo among patients with IgG4-related disease. Glucocorticoid use was lower and the incidence of remission was higher with obexelimab than with placebo.Fonte: NEJM Rheumatology — Categoria: medical_journals
Obexelimab and the Promise of Nondepleting B-Cell Therapy in IgG4-Related Disease — NEJM Rheumatology
IgG4-related disease has emerged as one of the clearest human models for understanding the role of B-lineage cells in immune-mediated inflammation. Although glucocorticoids remain effective for inducing remission, relapse during tapering is common, cumulative toxic effects are substantial, and durable disease control r…
Andes Virus — A Clinical Review — NEJM Pulmonary-critical-care
Andes virus, the sole orthohantavirus with documented human-to-human transmission, causes hantavirus pulmonary syndrome (case fatality rate, 25 to 40%). Aggressive supportive care and strict infection-control measures are needed.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
The Mayor — NEJM Neurology-neurosurgery
When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Vaping for Crypto — Smart Devices, Risky Business — NEJM Pediatrics
Recently launched smart vaping devices provide financial incentives tethered to use or engagement metrics. The addictive potential of such devices poses public health concerns.Fonte: NEJM Pediatrics — Categoria: medical_journals
Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults — NEJM Neurology-neurosurgery
In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Statins in Older Adults — Evidence at Last — NEJM Neurology-neurosurgery
For decades, one of the most important unresolved questions in preventive cardiovascular medicine has been whether statin therapy should be initiated for primary prevention in healthy older adults. Although age is among the strongest determinants of absolute risk, the benefits of statin therapy beyond 70 to 75 years of…
Serotonin Syndrome — NEJM Neurology-neurosurgery
A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video).Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Bilateral Pacing Neuromuscular Prosthesis for Laryngeal Paralysis — NEJM Neurology-neurosurgery
In four patients with bilateral vocal-fold paralysis, bilateral neuromuscular laryngeal pacing was found to restore vocal-fold abduction, increase inspiratory flow, and preserve voice and swallowing function.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Thyroglossal Duct Cyst — NEJM Pediatrics
A 6-year-old boy presented with an asymptomatic lump on the neck. Physical examination showed a nontender, midline mass in the anterior neck; ultrasonography showed a well-defined, hypoechoic mass and normal thyroid gland.Fonte: NEJM Pediatrics — Categoria: medical_journals
Opioid-Settlement Funds — Lessons from Tobacco — NEJM Health policy
Settlements of lawsuits against opioid manufacturers and other entities will shape drug policy for decades. Attention is needed to ensure that the funds will be dedicated to evidence-based activities.Fonte: NEJM Health policy — Categoria: medical_journals
Joint Clinical Assessments — A New Chapter in European Pharmaceutical Policy — NEJM Health policy
A new European Union regulation introduces a centralized clinical assessment process for comparing the effectiveness and safety of new medicines with those of the standards of care in various countries.Fonte: NEJM Health policy — Categoria: medical_journals
Billing for Messaging on the Patient Portal — NEJM Health policy
This feature focusing on a primary care physician who receives many messages on the online patient portal offers a case vignette accompanied by two essays, one recommending billing for such messaging and the other recommending not billing.Fonte: NEJM Health policy — Categoria: medical_journals
Giredestrant plus Everolimus in Advanced Breast Cancer — NEJM Hematology-oncology
In ER-positive, HER2-negative advanced breast cancer, giredestrant, an ER degrader and full ER antagonist, plus everolimus led to longer progression-free survival than standard endocrine therapy–everolimus; safety was similar.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults — NEJM Geriatrics-Aging
In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Vaping for Crypto — Smart Devices, Risky Business — NEJM Health policy
Recently launched smart vaping devices provide financial incentives tethered to use or engagement metrics. The addictive potential of such devices poses public health concerns.Fonte: NEJM Health policy — Categoria: medical_journals
An Echo Unheard — NEJM Infectious diseases
A 58-year-old woman with previously stable hearing impairment was admitted for rapidly progressive bilateral hearing loss. She reported no headache, vertigo, tinnitus, or dizziness.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Gold Standard Science and Biomedical Research — Principles, Governance, and Scientific Independence — NEJM Health policy
Though aspects of the U.S. Gold Standard Science initiative reflect valid standards, methodologic standards must be applied without selective use, political distortion, or erosion of scientific independence.Fonte: NEJM Health policy — Categoria: medical_journals
Double Take: Tobacco-Cessation Treatment for Global Impact — NEJM Health policy
This Double Take video describes the burden of global tobacco use and examines evidence-based tobacco-cessation strategies, including their implementation and associated challenges in India and Vietnam.Fonte: NEJM Health policy — Categoria: medical_journals
Andes Virus — A Clinical Review — NEJM Infectious diseases
Andes virus, the sole orthohantavirus with documented human-to-human transmission, causes hantavirus pulmonary syndrome (case fatality rate, 25 to 40%). Aggressive supportive care and strict infection-control measures are needed.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Statins in Older Adults — Evidence at Last — NEJM Geriatrics-Aging
For decades, one of the most important unresolved questions in preventive cardiovascular medicine has been whether statin therapy should be initiated for primary prevention in healthy older adults. Although age is among the strongest determinants of absolute risk, the benefits of statin therapy beyond 70 to 75 years of…
Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment — NEJM Infectious diseases
Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Durability of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 with CTX310 — NEJM Genetics
In a phase 1a trial, one-time CRISPR-Cas9 gene editing with CTX310 was associated with no treatment-related dose-limiting toxic effects and with sustained reductions in ANGPTL3 and atherogenic lipids at 1 year.Fonte: NEJM Genetics — Categoria: medical_journals
Joint Clinical Assessments — A New Chapter in European Pharmaceutical Policy — NEJM Hematology-oncology
A new European Union regulation introduces a centralized clinical assessment process for comparing the effectiveness and safety of new medicines with those of the standards of care in various countries.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
The Mayor — NEJM Gastroenterology
When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.Fonte: NEJM Gastroenterology — Categoria: medical_journals
An Echo Unheard — NEJM Clinical Medicine
A 58-year-old woman with previously stable hearing impairment was admitted for rapidly progressive bilateral hearing loss. She reported no headache, vertigo, tinnitus, or dizziness.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
The Mayor — NEJM Clinical Medicine
When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Gold Standard Science and Biomedical Research — Principles, Governance, and Scientific Independence — NEJM Clinical Medicine
Though aspects of the U.S. Gold Standard Science initiative reflect valid standards, methodologic standards must be applied without selective use, political distortion, or erosion of scientific independence.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Statins in Older Adults — Evidence at Last — NEJM Clinical Medicine
For decades, one of the most important unresolved questions in preventive cardiovascular medicine has been whether statin therapy should be initiated for primary prevention in healthy older adults. Although age is among the strongest determinants of absolute risk, the benefits of statin therapy beyond 70 to 75 years of…
Serotonin Syndrome — NEJM Clinical Medicine
A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video).Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Thyroglossal Duct Cyst — NEJM Clinical Medicine
A 6-year-old boy presented with an asymptomatic lump on the neck. Physical examination showed a nontender, midline mass in the anterior neck; ultrasonography showed a well-defined, hypoechoic mass and normal thyroid gland.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Billing for Messaging on the Patient Portal — NEJM Clinical Medicine
This feature focusing on a primary care physician who receives many messages on the online patient portal offers a case vignette accompanied by two essays, one recommending billing for such messaging and the other recommending not billing.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Obexelimab and the Promise of Nondepleting B-Cell Therapy in IgG4-Related Disease — NEJM Clinical Medicine
IgG4-related disease has emerged as one of the clearest human models for understanding the role of B-lineage cells in immune-mediated inflammation. Although glucocorticoids remain effective for inducing remission, relapse during tapering is common, cumulative toxic effects are substantial, and durable disease control r…
Durability of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 with CTX310 — NEJM Clinical Medicine
In a phase 1a trial, one-time CRISPR-Cas9 gene editing with CTX310 was associated with no treatment-related dose-limiting toxic effects and with sustained reductions in ANGPTL3 and atherogenic lipids at 1 year.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Double Take: Tobacco-Cessation Treatment for Global Impact — NEJM Clinical Medicine
This Double Take video describes the burden of global tobacco use and examines evidence-based tobacco-cessation strategies, including their implementation and associated challenges in India and Vietnam.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Obexelimab for the Treatment of IgG4-Related Disease — NEJM Clinical Medicine
In a phase 3 trial, obexelimab led to a lower risk of disease flares than placebo among patients with IgG4-related disease. Glucocorticoid use was lower and the incidence of remission was higher with obexelimab than with placebo.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Serotonin Syndrome — NEJM Emergency Medicine
A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video).Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Andes Virus — A Clinical Review — NEJM Emergency Medicine
Andes virus, the sole orthohantavirus with documented human-to-human transmission, causes hantavirus pulmonary syndrome (case fatality rate, 25 to 40%). Aggressive supportive care and strict infection-control measures are needed.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults — NEJM Cardiology
In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival.Fonte: NEJM Cardiology — Categoria: medical_journals
Statins in Older Adults — Evidence at Last — NEJM Cardiology
For decades, one of the most important unresolved questions in preventive cardiovascular medicine has been whether statin therapy should be initiated for primary prevention in healthy older adults. Although age is among the strongest determinants of absolute risk, the benefits of statin therapy beyond 70 to 75 years of…
Durability of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 with CTX310 — NEJM Cardiology
In a phase 1a trial, one-time CRISPR-Cas9 gene editing with CTX310 was associated with no treatment-related dose-limiting toxic effects and with sustained reductions in ANGPTL3 and atherogenic lipids at 1 year.Fonte: NEJM Cardiology — Categoria: medical_journals
Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults — NEJM Clinical Medicine
In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Obexelimab for the Treatment of IgG4-Related Disease — NEJM Allergy-Immunology
In a phase 3 trial, obexelimab led to a lower risk of disease flares than placebo among patients with IgG4-related disease. Glucocorticoid use was lower and the incidence of remission was higher with obexelimab than with placebo.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
An Echo Unheard — NEJM Allergy-Immunology
A 58-year-old woman with previously stable hearing impairment was admitted for rapidly progressive bilateral hearing loss. She reported no headache, vertigo, tinnitus, or dizziness.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Obexelimab and the Promise of Nondepleting B-Cell Therapy in IgG4-Related Disease — NEJM Allergy-Immunology
IgG4-related disease has emerged as one of the clearest human models for understanding the role of B-lineage cells in immune-mediated inflammation. Although glucocorticoids remain effective for inducing remission, relapse during tapering is common, cumulative toxic effects are substantial, and durable disease control r…
Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity — NEJM Pulmonary-critical-care
In this trial involving participants with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity — NEJM Rheumatology
In this trial involving participants with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events.Fonte: NEJM Rheumatology — Categoria: medical_journals
Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity — NEJM Clinical Medicine
In this trial involving participants with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity — NEJM Gastroenterology
In this trial involving participants with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity — NEJM Allergy-Immunology
In this trial involving participants with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity — NEJM Endocrinology
In this trial involving participants with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events.Fonte: NEJM Endocrinology — Categoria: medical_journals
The Mayor — NEJM Surgery
When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.Fonte: NEJM Surgery — Categoria: public_health
Serotonin Syndrome — NEJM Pulmonary-critical-care
A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video).Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
The Mayor — NEJM Neurology-neurosurgery
When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Serotonin Syndrome — NEJM Neurology-neurosurgery
A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video).Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Vaping for Crypto — Smart Devices, Risky Business — NEJM Pediatrics
Recently launched smart vaping devices provide financial incentives tethered to use or engagement metrics. The addictive potential of such devices poses public health concerns.Fonte: NEJM Pediatrics — Categoria: medical_journals
Opioid-Settlement Funds — Lessons from Tobacco — NEJM Health policy
Settlements of lawsuits against opioid manufacturers and other entities will shape drug policy for decades. Attention is needed to ensure that the funds will be dedicated to evidence-based activities.Fonte: NEJM Health policy — Categoria: medical_journals
Joint Clinical Assessments — A New Chapter in European Pharmaceutical Policy — NEJM Health policy
A new European Union regulation introduces a centralized clinical assessment process for comparing the effectiveness and safety of new medicines with those of the standards of care in various countries.Fonte: NEJM Health policy — Categoria: medical_journals
Vaping for Crypto — Smart Devices, Risky Business — NEJM Health policy
Recently launched smart vaping devices provide financial incentives tethered to use or engagement metrics. The addictive potential of such devices poses public health concerns.Fonte: NEJM Health policy — Categoria: medical_journals
Joint Clinical Assessments — A New Chapter in European Pharmaceutical Policy — NEJM Hematology-oncology
A new European Union regulation introduces a centralized clinical assessment process for comparing the effectiveness and safety of new medicines with those of the standards of care in various countries.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
The Mayor — NEJM Gastroenterology
When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Serotonin Syndrome — NEJM Clinical Medicine
A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video).Fonte: NEJM Clinical Medicine — Categoria: medical_journals
The Mayor — NEJM Clinical Medicine
When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Serotonin Syndrome — NEJM Emergency Medicine
A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video).Fonte: NEJM Emergency Medicine — Categoria: medical_journals
IARC Perspective on Lung Cancer Screening — NEJM Hematology-oncology
The 21st volume of the IARC Handbooks summarizes and evaluates evidence for the benefits and harms of lung cancer screening with low-dose CT or chest radiography and assesses tools and strategies to improve screening.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Etuvetidigene Autotemcel for the Treatment of Wiskott–Aldrich Syndrome — NEJM Pediatrics
Persons with Wiskott–Aldrich syndrome were treated with an autologous gene therapy consisting of hematopoietic stem and progenitor cells transduced ex vivo with a lentiviral vector encoding WAS complementary DNA.Fonte: NEJM Pediatrics — Categoria: medical_journals
Congenital Amniotic Band Sequence — NEJM Pediatrics
A baby girl was noted to have swelling and cyanosis of the left arm, shoulder, and chest after birth. An MRI showed two fibrous bands penetrating the deep fascia.Fonte: NEJM Pediatrics — Categoria: medical_journals
The End of the War on Biomedical Science? — NEJM Pediatrics
The turmoil of the past 20 months has inflicted lasting damage on American science and public health. But history and recent events suggest that the attacks will subside.Fonte: NEJM Pediatrics — Categoria: medical_journals
Declining Child Health in the United States — Addressing the Developmental Ecosystem — NEJM Pediatrics
To address drivers of poor child health, society should move from responding to health crises one symptom and one child at a time to reimagining ecosystems in ways that facilitate healthy development.Fonte: NEJM Pediatrics — Categoria: medical_journals
Gaps and Borders — NEJM Pediatrics
How can anyone in the U.S. medical community help children facing down the demons unleashed on them by the human traffickers entrusted with delivering them to better lives?Fonte: NEJM Pediatrics — Categoria: medical_journals
Cumulative Hematologic Morbidity and Outcomes in Shwachman–Diamond Syndrome — NEJM Pediatrics
In an international cohort of 865 patients, Shwachman–Diamond syndrome was associated with a high risk of myeloid cancer and poor survival. Early hematopoietic stem-cell transplantation for high-risk features had a potential benefit.Fonte: NEJM Pediatrics — Categoria: medical_journals
Case 27-2026: A 4-Year-Old Boy with Fatigue, Imbalance, and Frequent Falls — NEJM Pediatrics
A 4-year-old boy presented with fatigue and frequent falls. After falling, he could not stand up using his legs and would instead push himself up with his hands. The aminotransferase levels were elevated. A diagnosis was made.Fonte: NEJM Pediatrics — Categoria: medical_journals
Congenital Amniotic Band Sequence — NEJM Obstetrics-gynecology
A baby girl was noted to have swelling and cyanosis of the left arm, shoulder, and chest after birth. An MRI showed two fibrous bands penetrating the deep fascia.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond — NEJM Neurology-neurosurgery
Drs. Yanagisawa and Mignot received the 2026 Albert Lasker Award for Basic Medical Research for their pivotal work in the discovery of the orexin (hypocretin) system and its role in narcolepsy.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials — NEJM Neurology-neurosurgery
In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Case 27-2026: A 4-Year-Old Boy with Fatigue, Imbalance, and Frequent Falls — NEJM Neurology-neurosurgery
A 4-year-old boy presented with fatigue and frequent falls. After falling, he could not stand up using his legs and would instead push himself up with his hands. The aminotransferase levels were elevated. A diagnosis was made.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Cerebral Schistosomiasis — NEJM Neurology-neurosurgery
A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Targeted Treatment for Narcolepsy Type 1 — NEJM Neurology-neurosurgery
For more than 25 years, narcolepsy type 1 (formerly narcolepsy with cataplexy) has been known to be associated with a deficiency of orexin within cerebrospinal fluid (CSF) and reduced staining of orexin-containing hypothalamic neurons on autopsy.1 Subsequent work has led to the current understanding of narcolepsy type …
The End of the War on Biomedical Science? — NEJM Infectious diseases
The turmoil of the past 20 months has inflicted lasting damage on American science and public health. But history and recent events suggest that the attacks will subside.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Cerebral Schistosomiasis — NEJM Infectious diseases
A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Oya Virus in a Patient with Severe Hepatitis, Enteritis, and Coagulopathy — NEJM Infectious diseases
Oya virus, an orthobunyavirus, was identified in a 54-year-old woman who had sepsis-like symptoms, including leukocytosis, thrombocytopenia, elevated liver-function values, and disseminated intravascular coagulation.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Etuvetidigene Autotemcel for the Treatment of Wiskott–Aldrich Syndrome — NEJM Hematology-oncology
Persons with Wiskott–Aldrich syndrome were treated with an autologous gene therapy consisting of hematopoietic stem and progenitor cells transduced ex vivo with a lentiviral vector encoding WAS complementary DNA.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Science behind the Study: Anito-cel for Multiple Myeloma — NEJM Hematology-oncology
The author describes the science behind a phase 1 study of anitocabtagene autoleucel, a CAR T cell that deploys a CAR with a novel synthetic antigen-binding domain, in patients with multiple myeloma.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
A Cure Out of Most Patients’ Reach — Sickle Cell Disease in the Gene-Therapy Era — NEJM Hematology-oncology
Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treatment.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Cumulative Hematologic Morbidity and Outcomes in Shwachman–Diamond Syndrome — NEJM Hematology-oncology
In an international cohort of 865 patients, Shwachman–Diamond syndrome was associated with a high risk of myeloid cancer and poor survival. Early hematopoietic stem-cell transplantation for high-risk features had a potential benefit.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Phase 1 Study of Anito-cel, a d-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma — NEJM Hematology-oncology
In a phase 1 study of anito-cel, a CAR T-cell therapy, for relapsed or refractory myeloma, all 38 patients had a response. Severe cytokine release syndrome and immune effector cell–associated neurotoxicity syndrome were rare.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Clinical Uses of Common Genetic Variants Associated with Common Diseases — NEJM Hematology-oncology
The authors review the ways common genetic variants, polygenic risk scores, and pharmacogenomic genotyping may be useful in the prevention of common diseases and the treatment of common diseases after diagnosis.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Clinical Uses of Common Genetic Variants Associated with Common Diseases — NEJM Health policy
The authors review the ways common genetic variants, polygenic risk scores, and pharmacogenomic genotyping may be useful in the prevention of common diseases and the treatment of common diseases after diagnosis.Fonte: NEJM Health policy — Categoria: medical_journals
The End of the War on Biomedical Science? — NEJM Health policy
The turmoil of the past 20 months has inflicted lasting damage on American science and public health. But history and recent events suggest that the attacks will subside.Fonte: NEJM Health policy — Categoria: medical_journals
A Cure Out of Most Patients’ Reach — Sickle Cell Disease in the Gene-Therapy Era — NEJM Health policy
Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treatment.Fonte: NEJM Health policy — Categoria: medical_journals
Etuvetidigene Autotemcel for the Treatment of Wiskott–Aldrich Syndrome — NEJM Genetics
Persons with Wiskott–Aldrich syndrome were treated with an autologous gene therapy consisting of hematopoietic stem and progenitor cells transduced ex vivo with a lentiviral vector encoding WAS complementary DNA.Fonte: NEJM Genetics — Categoria: medical_journals
Clinical Uses of Common Genetic Variants Associated with Common Diseases — NEJM Genetics
The authors review the ways common genetic variants, polygenic risk scores, and pharmacogenomic genotyping may be useful in the prevention of common diseases and the treatment of common diseases after diagnosis.Fonte: NEJM Genetics — Categoria: medical_journals
Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials — NEJM Genetics
In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common.Fonte: NEJM Genetics — Categoria: medical_journals
Targeted Treatment for Narcolepsy Type 1 — NEJM Genetics
For more than 25 years, narcolepsy type 1 (formerly narcolepsy with cataplexy) has been known to be associated with a deficiency of orexin within cerebrospinal fluid (CSF) and reduced staining of orexin-containing hypothalamic neurons on autopsy.1 Subsequent work has led to the current understanding of narcolepsy type …
The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond — NEJM Genetics
Drs. Yanagisawa and Mignot received the 2026 Albert Lasker Award for Basic Medical Research for their pivotal work in the discovery of the orexin (hypocretin) system and its role in narcolepsy.Fonte: NEJM Genetics — Categoria: medical_journals
A Cure Out of Most Patients’ Reach — Sickle Cell Disease in the Gene-Therapy Era — NEJM Genetics
Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treatment.Fonte: NEJM Genetics — Categoria: medical_journals
Cumulative Hematologic Morbidity and Outcomes in Shwachman–Diamond Syndrome — NEJM Genetics
In an international cohort of 865 patients, Shwachman–Diamond syndrome was associated with a high risk of myeloid cancer and poor survival. Early hematopoietic stem-cell transplantation for high-risk features had a potential benefit.Fonte: NEJM Genetics — Categoria: medical_journals
Science behind the Study: Anito-cel for Multiple Myeloma — NEJM Genetics
The author describes the science behind a phase 1 study of anitocabtagene autoleucel, a CAR T cell that deploys a CAR with a novel synthetic antigen-binding domain, in patients with multiple myeloma.Fonte: NEJM Genetics — Categoria: medical_journals
Targeted Treatment for Narcolepsy Type 1 — NEJM Endocrinology
For more than 25 years, narcolepsy type 1 (formerly narcolepsy with cataplexy) has been known to be associated with a deficiency of orexin within cerebrospinal fluid (CSF) and reduced staining of orexin-containing hypothalamic neurons on autopsy.1 Subsequent work has led to the current understanding of narcolepsy type …
Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials — NEJM Endocrinology
In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common.Fonte: NEJM Endocrinology — Categoria: medical_journals
Declining Child Health in the United States — Addressing the Developmental Ecosystem — NEJM Endocrinology
To address drivers of poor child health, society should move from responding to health crises one symptom and one child at a time to reimagining ecosystems in ways that facilitate healthy development.Fonte: NEJM Endocrinology — Categoria: medical_journals
The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond — NEJM Endocrinology
Drs. Yanagisawa and Mignot received the 2026 Albert Lasker Award for Basic Medical Research for their pivotal work in the discovery of the orexin (hypocretin) system and its role in narcolepsy.Fonte: NEJM Endocrinology — Categoria: medical_journals
Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk — NEJM Clinical Medicine
In patients with atrial fibrillation and intermediate stroke risk, direct oral anticoagulation led to a lower risk of stroke, systemic embolism, major bleeding, or death from cardiovascular causes than no anticoagulation.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Case 27-2026: A 4-Year-Old Boy with Fatigue, Imbalance, and Frequent Falls — NEJM Clinical Medicine
A 4-year-old boy presented with fatigue and frequent falls. After falling, he could not stand up using his legs and would instead push himself up with his hands. The aminotransferase levels were elevated. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Gaps and Borders — NEJM Clinical Medicine
How can anyone in the U.S. medical community help children facing down the demons unleashed on them by the human traffickers entrusted with delivering them to better lives?Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Cerebral Schistosomiasis — NEJM Clinical Medicine
A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Targeted Treatment for Narcolepsy Type 1 — NEJM Clinical Medicine
For more than 25 years, narcolepsy type 1 (formerly narcolepsy with cataplexy) has been known to be associated with a deficiency of orexin within cerebrospinal fluid (CSF) and reduced staining of orexin-containing hypothalamic neurons on autopsy.1 Subsequent work has led to the current understanding of narcolepsy type …
A Cure Out of Most Patients’ Reach — Sickle Cell Disease in the Gene-Therapy Era — NEJM Clinical Medicine
Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treatment.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Anticoagulation for Atrial Fibrillation with a Single Risk Factor for Stroke — NEJM Clinical Medicine
Stroke is a severe and common complication of atrial fibrillation. Anticoagulation with vitamin K antagonists or with direct oral anticoagulants (DOACs) prevents the majority of strokes in patients with atrial fibrillation and at least two clinical risk factors for stroke (Table 1).1 Patients who receive DOACs or vitam…
Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials — NEJM Clinical Medicine
In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Congenital Amniotic Band Sequence — NEJM Clinical Medicine
A baby girl was noted to have swelling and cyanosis of the left arm, shoulder, and chest after birth. An MRI showed two fibrous bands penetrating the deep fascia.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials — NEJM Cardiology
In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common.Fonte: NEJM Cardiology — Categoria: medical_journals
Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk — NEJM Cardiology
In patients with atrial fibrillation and intermediate stroke risk, direct oral anticoagulation led to a lower risk of stroke, systemic embolism, major bleeding, or death from cardiovascular causes than no anticoagulation.Fonte: NEJM Cardiology — Categoria: medical_journals
Anticoagulation for Atrial Fibrillation with a Single Risk Factor for Stroke — NEJM Cardiology
Stroke is a severe and common complication of atrial fibrillation. Anticoagulation with vitamin K antagonists or with direct oral anticoagulants (DOACs) prevents the majority of strokes in patients with atrial fibrillation and at least two clinical risk factors for stroke (Table 1).1 Patients who receive DOACs or vitam…
Etuvetidigene Autotemcel for the Treatment of Wiskott–Aldrich Syndrome — NEJM Allergy-Immunology
Persons with Wiskott–Aldrich syndrome were treated with an autologous gene therapy consisting of hematopoietic stem and progenitor cells transduced ex vivo with a lentiviral vector encoding WAS complementary DNA.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Targeted Treatment for Narcolepsy Type 1 — NEJM Allergy-Immunology
For more than 25 years, narcolepsy type 1 (formerly narcolepsy with cataplexy) has been known to be associated with a deficiency of orexin within cerebrospinal fluid (CSF) and reduced staining of orexin-containing hypothalamic neurons on autopsy.1 Subsequent work has led to the current understanding of narcolepsy type …
The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond — NEJM Allergy-Immunology
Drs. Yanagisawa and Mignot received the 2026 Albert Lasker Award for Basic Medical Research for their pivotal work in the discovery of the orexin (hypocretin) system and its role in narcolepsy.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials — NEJM Allergy-Immunology
In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis — NEJM Hematology-oncology
In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
A Step in the Search for the Elusive Holy Grail of Early Detection of Cancer — NEJM Hematology-oncology
The diagnosis of cancer at earlier stages is generally associated with improved survival. Detecting circulating tumor–derived cell-free DNA (cfDNA) is an established method of monitoring the response to therapy for many cancer types, particularly hematopoietic and metastatic cancers — which leads to the question of whe…
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis — NEJM Clinical Medicine
In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis — NEJM Genetics
In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone.Fonte: NEJM Genetics — Categoria: medical_journals
A Step in the Search for the Elusive Holy Grail of Early Detection of Cancer — NEJM Genetics
The diagnosis of cancer at earlier stages is generally associated with improved survival. Detecting circulating tumor–derived cell-free DNA (cfDNA) is an established method of monitoring the response to therapy for many cancer types, particularly hematopoietic and metastatic cancers — which leads to the question of whe…
The End of the War on Biomedical Science? — NEJM Pediatrics
The turmoil of the past 20 months has inflicted lasting damage on American science and public health. But history and recent events suggest that the attacks will subside.Fonte: NEJM Pediatrics — Categoria: medical_journals
Declining Child Health in the United States — Addressing the Developmental Ecosystem — NEJM Pediatrics
To address drivers of poor child health, society should move from responding to health crises one symptom and one child at a time to reimagining ecosystems in ways that facilitate healthy development.Fonte: NEJM Pediatrics — Categoria: medical_journals
Gaps and Borders — NEJM Pediatrics
How can anyone in the U.S. medical community help children facing down the demons unleashed on them by the human traffickers entrusted with delivering them to better lives?Fonte: NEJM Pediatrics — Categoria: medical_journals
A Cure Out of Most Patients’ Reach — Sickle Cell Disease in the Gene-Therapy Era — NEJM Hematology-oncology
Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treatment.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
The End of the War on Biomedical Science? — NEJM Infectious diseases
The turmoil of the past 20 months has inflicted lasting damage on American science and public health. But history and recent events suggest that the attacks will subside.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Cerebral Schistosomiasis — NEJM Infectious diseases
A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe.Fonte: NEJM Infectious diseases — Categoria: medical_journals
The End of the War on Biomedical Science? — NEJM Health policy
The turmoil of the past 20 months has inflicted lasting damage on American science and public health. But history and recent events suggest that the attacks will subside.Fonte: NEJM Health policy — Categoria: medical_journals
A Cure Out of Most Patients’ Reach — Sickle Cell Disease in the Gene-Therapy Era — NEJM Health policy
Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treatment.Fonte: NEJM Health policy — Categoria: medical_journals
Cerebral Schistosomiasis — NEJM Clinical Medicine
A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Gaps and Borders — NEJM Clinical Medicine
How can anyone in the U.S. medical community help children facing down the demons unleashed on them by the human traffickers entrusted with delivering them to better lives?Fonte: NEJM Clinical Medicine — Categoria: medical_journals
A Cure Out of Most Patients’ Reach — Sickle Cell Disease in the Gene-Therapy Era — NEJM Clinical Medicine
Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treatment.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
A Cure Out of Most Patients’ Reach — Sickle Cell Disease in the Gene-Therapy Era — NEJM Genetics
Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treatment.Fonte: NEJM Genetics — Categoria: medical_journals
Cerebral Schistosomiasis — NEJM Neurology-neurosurgery
A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Durability of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 with CTX310 — NEJM Cardiology
In a phase 1a trial, one-time CRISPR-Cas9 gene editing with CTX310 was associated with no treatment-related dose-limiting toxic effects and with sustained reductions in ANGPTL3 and atherogenic lipids at 1 year.Fonte: NEJM Cardiology — Categoria: medical_journals
Declining Child Health in the United States — Addressing the Developmental Ecosystem — NEJM Endocrinology
To address drivers of poor child health, society should move from responding to health crises one symptom and one child at a time to reimagining ecosystems in ways that facilitate healthy development.Fonte: NEJM Endocrinology — Categoria: medical_journals
Sodium Bicarbonate in Critical Illness — A New Chapter for the Book — NEJM Pulmonary-critical-care
Acute metabolic acidosis is common in hospitalized patients owing to conditions such as shock, kidney disease, and diabetic ketoacidosis. While the underlying cause is being treated, it may be tempting to use buffer solutions concurrently to try to raise extracellular pH, particularly in critically ill patients. Clinic…
Human Adenovirus B3–Induced Immune Thrombocytopenia and Thrombosis — NEJM Pulmonary-critical-care
Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock — NEJM Pulmonary-critical-care
Among critically ill adults with metabolic acidosis receiving vasopressors in the ICU, sodium bicarbonate did not lead to a lower risk of major adverse kidney events within 30 days than placebo.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Celiac-Artery Dissection — NEJM Surgery
A 72-year-old man with hypertension, hyperlipidemia, and a stable ascending aortic aneurysm presented with sudden-onset, severe chest pain. CTA of the chest, abdomen, and pelvis showed a celiac-artery dissection.Fonte: NEJM Surgery — Categoria: public_health
The Epstein Files Transparency Act and the Health of Trafficked Children — NEJM Obstetrics-gynecology
Policymakers have so far failed to hold perpetrators in Jeffrey Epstein’s trafficking network accountable, but the medical and public health community should confront the resulting health crisis.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia — NEJM Pediatrics
Among children with high-risk B-cell acute lymphoblastic leukemia, two cycles of blinatumomab led to a higher 4-year event-free survival than two cycles of chemotherapy (83.0% vs. 70.3%), with a lower risk of serious infection.Fonte: NEJM Pediatrics — Categoria: medical_journals
Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy — NEJM Pediatrics
Among infants with a family history of allergy, a maternal diet high in eggs and peanuts during pregnancy and lactation did not result in a lower risk of egg or peanut allergy at 1 year than a standard diet.Fonte: NEJM Pediatrics — Categoria: medical_journals
Blinatumomab — A New Standard of Care in Acute Lymphoblastic Leukemia — NEJM Pediatrics
Research involving the treatment of pediatric acute lymphoblastic leukemia (ALL) established the paradigm for improving survival in cancer. In iterative clinical trials conducted by cooperative groups, long-term survival has improved from less than 10% to 90% owing to the use of improved multidrug regimens and treatmen…
Maternal Allergen Consumption and Infant Food Allergy — Reassurance, Not Prescription — NEJM Pediatrics
Food-allergy prevention has undergone a major conceptual shift over the past decade. After years in which avoidance of allergenic foods during infancy, and sometimes during pregnancy and lactation, was considered to be a biologically plausible strategy to prevent food allergy, randomized trials of early infant feeding …
The Epstein Files Transparency Act and the Health of Trafficked Children — NEJM Pediatrics
Policymakers have so far failed to hold perpetrators in Jeffrey Epstein’s trafficking network accountable, but the medical and public health community should confront the resulting health crisis.Fonte: NEJM Pediatrics — Categoria: medical_journals
Maternal Allergen Consumption and Infant Food Allergy — Reassurance, Not Prescription — NEJM Obstetrics-gynecology
Food-allergy prevention has undergone a major conceptual shift over the past decade. After years in which avoidance of allergenic foods during infancy, and sometimes during pregnancy and lactation, was considered to be a biologically plausible strategy to prevent food allergy, randomized trials of early infant feeding …
Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy — NEJM Obstetrics-gynecology
Among infants with a family history of allergy, a maternal diet high in eggs and peanuts during pregnancy and lactation did not result in a lower risk of egg or peanut allergy at 1 year than a standard diet.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Human Adenovirus B3–Induced Immune Thrombocytopenia and Thrombosis — NEJM Pediatrics
Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease.Fonte: NEJM Pediatrics — Categoria: medical_journals
Colorectal Cancer Risk among Patients with Serrated Polyps — NEJM Hematology-oncology
In this prospective trial, patients with serrated polyps had a low 5-year risk of colorectal cancer (1.0%).Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Honoring the Legacy of the HIV Epidemic — NEJM Infectious diseases
Progress against the U.S. HIV epidemic is stalling, owing in part to government attacks and fear. But clinicians, patients, and activists can learn from the epidemic’s early heroes and find ways to advance.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Human Adenovirus B3–Induced Immune Thrombocytopenia and Thrombosis — NEJM Infectious diseases
Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Short or Long Antibiotic Regimens in Orthopedics — NEJM Infectious diseases
In a randomized trial involving adults who received local antibiotics during surgery for orthopedic infection, a short duration of systemic antibiotics was noninferior to a long duration regarding treatment failure at 12 months.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock — NEJM Nephrology
Among critically ill adults with metabolic acidosis receiving vasopressors in the ICU, sodium bicarbonate did not lead to a lower risk of major adverse kidney events within 30 days than placebo.Fonte: NEJM Nephrology — Categoria: medical_journals
Sodium Bicarbonate in Critical Illness — A New Chapter for the Book — NEJM Nephrology
Acute metabolic acidosis is common in hospitalized patients owing to conditions such as shock, kidney disease, and diabetic ketoacidosis. While the underlying cause is being treated, it may be tempting to use buffer solutions concurrently to try to raise extracellular pH, particularly in critically ill patients. Clinic…
Case 26-2026: A 62-Year-Old Woman with Memory Loss, Anhedonia, and Temporal Wasting — NEJM Hematology-oncology
A 62-year-old woman with a history of stroke and metastatic breast cancer that was being treated with immunomodulator therapy presented with memory loss, confabulation, anhedonia, ataxia, and weight loss. A diagnosis was made.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Human Adenovirus B3–Induced Immune Thrombocytopenia and Thrombosis — NEJM Hematology-oncology
Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
When More Is Not Better — Colonoscopy Surveillance after High-Risk Adenomas — NEJM Hematology-oncology
Colonoscopy surveillance after the removal of adenomas is a cornerstone of the prevention of colorectal cancer. Guidelines in the United States and Europe have endorsed surveillance beginning at 3 years after the removal of advanced adenomas (defined as ≥1 adenoma with a diameter of ≥10 mm, high-grade dysplasia, or vil…
Late-Onset Pompe Disease — NEJM Neurology-neurosurgery
A 54-year-old woman presented to the emergency department with progressive asthenia, falls, and dyspnea. Physical examination and muscle biopsy provided clues to the diagnosis.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Initial Screening for Colorectal Cancer — NEJM Hematology-oncology
This feature about colorectal cancer screening in a 46-year-old man offers a case vignette accompanied by two essays, one recommending screening by colonoscopy and the other supporting use of a stool-based test.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Case 26-2026: A 62-Year-Old Woman with Memory Loss, Anhedonia, and Temporal Wasting — NEJM Neurology-neurosurgery
A 62-year-old woman with a history of stroke and metastatic breast cancer that was being treated with immunomodulator therapy presented with memory loss, confabulation, anhedonia, ataxia, and weight loss. A diagnosis was made.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals