NEJM
Aggiornamenti aggregati dai feed ufficiali del New England Journal of Medicine.
Jaccoud’s Arthropathy — NEJM Rheumatology
A woman presented with a 2-year history of pain, swelling, and stiffness in the wrists and fingers. Deformities were noted in her fingers and thumbs. When the hands were clenched into fists, the deformities resolved, as shown in a video.Fonte: NEJM Rheumatology — Categoria: medical_journals
Carbocisteine or Hypertonic Saline for Acute Respiratory Failure — NEJM Pulmonary-critical-care
Among critically ill adults with acute respiratory failure, neither carbocisteine nor hypertonic saline reduced the duration of mechanical ventilation, and each strategy was associated with harm.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Azithromycin for Preschoolers with Wheezing in the Emergency Department — NEJM Pulmonary-critical-care
Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the ED with wheezing, regardless of whether they tested positive for pathogenic bacteria.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Mucolytics in Respiratory Failure — A MARCH Forward — NEJM Pulmonary-critical-care
In patients with acute respiratory failure, difficulty managing respiratory secretions may contribute to adverse outcomes.1 Airway mucus is a multilayered substance consisting of a viscoelastic glycoprotein gel, a liquid layer, and a thin layer of surfactant.2 Mucus is cleared from the airway primarily by the action...…
First-Line Sunvozertinib in NSCLC with EGFR Exon 20 Insertion Mutations — NEJM Pulmonary-critical-care
In NSCLC with EGFR exon 20 insertions, first-line sunvozertinib led to longer progression-free survival than chemotherapy. The most common adverse events of grade 3 or higher were elevated creatine kinase, diarrhea, and anemia.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
No to Azithromycin for Preschoolers with Acute Wheezing in the Emergency Department — NEJM Pulmonary-critical-care
Acute wheezing attacks are common in preschool-age children. These attacks lead to impaired quality of life1 and are associated with trajectories of poor lung function that may be lifelong, especially in children who are exposed to tobacco smoke and have allergic sensitization.2 Despite increased focus on...Fonte: NEJM…
Case 24-2026: A 74-Year-Old Man with Dyspnea, Proximal Muscle Weakness, and Hypoxemia — NEJM Rheumatology
A 74-year-old man with myasthenia gravis was evaluated for dyspnea, proximal muscle weakness, hypoxemia, and a painful tongue lesion. Medications included prednisone and mycophenolate mofetil. A diagnosis was made.Fonte: NEJM Rheumatology — Categoria: medical_journals
Drug-Induced Subacute Cutaneous Lupus Erythematosus — NEJM Rheumatology
A 73-year-old woman with rheumatoid arthritis and a 10-month history of pantoprazole therapy presented with skin lesions on her torso. Annular polycyclic lesions were observed on her upper back.Fonte: NEJM Rheumatology — Categoria: medical_journals
Placement of a Catheter for Acute Peritoneal Dialysis — NEJM Surgery
This video demonstrates how to insert a catheter for emergency peritoneal dialysis in adults with a technique created specifically for environments that may have limited access to resources.Fonte: NEJM Surgery — Categoria: public_health
Azithromycin for Preschoolers with Wheezing in the Emergency Department — NEJM Pediatrics
Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the ED with wheezing, regardless of whether they tested positive for pathogenic bacteria.Fonte: NEJM Pediatrics — Categoria: medical_journals
No to Azithromycin for Preschoolers with Acute Wheezing in the Emergency Department — NEJM Pediatrics
Acute wheezing attacks are common in preschool-age children. These attacks lead to impaired quality of life1 and are associated with trajectories of poor lung function that may be lifelong, especially in children who are exposed to tobacco smoke and have allergic sensitization.2 Despite increased focus on...Fonte: NEJM…
Case 24-2026: A 74-Year-Old Man with Dyspnea, Proximal Muscle Weakness, and Hypoxemia — NEJM Neurology-neurosurgery
A 74-year-old man with myasthenia gravis was evaluated for dyspnea, proximal muscle weakness, hypoxemia, and a painful tongue lesion. Medications included prednisone and mycophenolate mofetil. A diagnosis was made.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Marijuana Rescheduling — A Game Changer for Research? — NEJM Neurology-neurosurgery
A proposed reclassification of medical marijuana products as Schedule III drugs would address only two of the three key barriers to research on marijuana’s safety and effectiveness for various indications.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Placement of a Catheter for Acute Peritoneal Dialysis — NEJM Nephrology
This video demonstrates how to insert a catheter for emergency peritoneal dialysis in adults with a technique created specifically for environments that may have limited access to resources.Fonte: NEJM Nephrology — Categoria: medical_journals
Pregnancies in Patients with Autoimmune Disease Receiving CAR T-Cell Therapy — NEJM Obstetrics-gynecology
Among 14 pregnancies in 13 patients with autoimmune disease who had undergone CAR T-cell therapy, early maternal and neonatal outcomes appeared reassuring, with no disease relapses reported and 8 healthy infants born to date.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Marijuana Rescheduling — A Game Changer for Research? — NEJM Health policy
A proposed reclassification of medical marijuana products as Schedule III drugs would address only two of the three key barriers to research on marijuana’s safety and effectiveness for various indications.Fonte: NEJM Health policy — Categoria: medical_journals
First-Line Sunvozertinib in NSCLC with EGFR Exon 20 Insertion Mutations — NEJM Hematology-oncology
In NSCLC with EGFR exon 20 insertions, first-line sunvozertinib led to longer progression-free survival than chemotherapy. The most common adverse events of grade 3 or higher were elevated creatine kinase, diarrhea, and anemia.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
The Broader Dangers of Abandoning SGM Health Research — NEJM Health policy
When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.Fonte: NEJM Health policy — Categoria: medical_journals
Myeloproliferative Neoplasms — NEJM Hematology-oncology
This review summarizes the pathogenesis and treatment of myeloproliferative neoplasms, highlighting the role of driver mutations, inflammation, and emerging targeted therapies that may achieve durable disease modification.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Marijuana Rescheduling — A Game Changer for Research? — NEJM Hematology-oncology
A proposed reclassification of medical marijuana products as Schedule III drugs would address only two of the three key barriers to research on marijuana’s safety and effectiveness for various indications.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Severe Plasmodium falciparum Malaria — NEJM Hematology-oncology
An 82-year-old man was brought to the ED after being “found down.” One week earlier, he had returned from a 1-month visit to Chad. A peripheral-blood smear showed ring-form trophozoites within erythrocytes.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Crew Resource Management — Navigating AI’s Automation Paradox — NEJM Health policy
The more capable an AI copilot appears, the more likely clinicians are to offload tasks to it, eroding skills required for detecting its errors. CRM can help overcome this “automation paradox.”Fonte: NEJM Health policy — Categoria: medical_journals
Severe Plasmodium falciparum Malaria — NEJM Infectious diseases
An 82-year-old man was brought to the ED after being “found down.” One week earlier, he had returned from a 1-month visit to Chad. A peripheral-blood smear showed ring-form trophozoites within erythrocytes.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Case 24-2026: A 74-Year-Old Man with Dyspnea, Proximal Muscle Weakness, and Hypoxemia — NEJM Infectious diseases
A 74-year-old man with myasthenia gravis was evaluated for dyspnea, proximal muscle weakness, hypoxemia, and a painful tongue lesion. Medications included prednisone and mycophenolate mofetil. A diagnosis was made.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Myeloproliferative Neoplasms — NEJM Genetics
This review summarizes the pathogenesis and treatment of myeloproliferative neoplasms, highlighting the role of driver mutations, inflammation, and emerging targeted therapies that may achieve durable disease modification.Fonte: NEJM Genetics — Categoria: medical_journals
Long-Term Survival of Hypoimmune Allogeneic Islets without Immunosuppression — NEJM Genetics
A patient with type 1 diabetes received genetically modified allogeneic islets and no immunosuppression. Results obtained through 14 months support β-cell function and a lack of immune response against the allograft.Fonte: NEJM Genetics — Categoria: medical_journals
Azithromycin for Preschoolers with Wheezing in the Emergency Department — NEJM Emergency Medicine
Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the ED with wheezing, regardless of whether they tested positive for pathogenic bacteria.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Placement of a Catheter for Acute Peritoneal Dialysis — NEJM Emergency Medicine
This video demonstrates how to insert a catheter for emergency peritoneal dialysis in adults with a technique created specifically for environments that may have limited access to resources.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
No to Azithromycin for Preschoolers with Acute Wheezing in the Emergency Department — NEJM Emergency Medicine
Acute wheezing attacks are common in preschool-age children. These attacks lead to impaired quality of life1 and are associated with trajectories of poor lung function that may be lifelong, especially in children who are exposed to tobacco smoke and have allergic sensitization.2 Despite increased focus on...Fonte: NEJM…
Drug-Induced Subacute Cutaneous Lupus Erythematosus — NEJM Dermatology
A 73-year-old woman with rheumatoid arthritis and a 10-month history of pantoprazole therapy presented with skin lesions on her torso. Annular polycyclic lesions were observed on her upper back.Fonte: NEJM Dermatology — Categoria: medical_journals
The Broader Dangers of Abandoning SGM Health Research — NEJM Endocrinology
When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.Fonte: NEJM Endocrinology — Categoria: medical_journals
Long-Term Survival of Hypoimmune Allogeneic Islets without Immunosuppression — NEJM Endocrinology
A patient with type 1 diabetes received genetically modified allogeneic islets and no immunosuppression. Results obtained through 14 months support β-cell function and a lack of immune response against the allograft.Fonte: NEJM Endocrinology — Categoria: medical_journals
Pregnancies in Patients with Autoimmune Disease Receiving CAR T-Cell Therapy — NEJM Endocrinology
Among 14 pregnancies in 13 patients with autoimmune disease who had undergone CAR T-cell therapy, early maternal and neonatal outcomes appeared reassuring, with no disease relapses reported and 8 healthy infants born to date.Fonte: NEJM Endocrinology — Categoria: medical_journals
Survodutide Once Weekly for the Treatment of Adults with Obesity — NEJM Endocrinology
In a phase 3 trial involving adults with obesity but without diabetes, the glucagon receptor–GLP-1 receptor dual agonist survodutide led to significantly greater reductions in body weight than placebo.Fonte: NEJM Endocrinology — Categoria: medical_journals
Long-Term Survival of Hypoimmune Allogeneic Islets without Immunosuppression — NEJM Allergy-Immunology
A patient with type 1 diabetes received genetically modified allogeneic islets and no immunosuppression. Results obtained through 14 months support β-cell function and a lack of immune response against the allograft.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Survodutide Once Weekly for the Treatment of Adults with Obesity — NEJM Cardiology
In a phase 3 trial involving adults with obesity but without diabetes, the glucagon receptor–GLP-1 receptor dual agonist survodutide led to significantly greater reductions in body weight than placebo.Fonte: NEJM Cardiology — Categoria: medical_journals
Pregnancies in Patients with Autoimmune Disease Receiving CAR T-Cell Therapy — NEJM Allergy-Immunology
Among 14 pregnancies in 13 patients with autoimmune disease who had undergone CAR T-cell therapy, early maternal and neonatal outcomes appeared reassuring, with no disease relapses reported and 8 healthy infants born to date.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Azithromycin for Preschoolers with Wheezing in the Emergency Department — NEJM Clinical Medicine
Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the ED with wheezing, regardless of whether they tested positive for pathogenic bacteria.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
No to Azithromycin for Preschoolers with Acute Wheezing in the Emergency Department — NEJM Clinical Medicine
Acute wheezing attacks are common in preschool-age children. These attacks lead to impaired quality of life1 and are associated with trajectories of poor lung function that may be lifelong, especially in children who are exposed to tobacco smoke and have allergic sensitization.2 Despite increased focus on...Fonte: NEJM…
Case 24-2026: A 74-Year-Old Man with Dyspnea, Proximal Muscle Weakness, and Hypoxemia — NEJM Allergy-Immunology
A 74-year-old man with myasthenia gravis was evaluated for dyspnea, proximal muscle weakness, hypoxemia, and a painful tongue lesion. Medications included prednisone and mycophenolate mofetil. A diagnosis was made.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Azithromycin for Preschoolers with Wheezing in the Emergency Department — NEJM Allergy-Immunology
Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the ED with wheezing, regardless of whether they tested positive for pathogenic bacteria.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Case 24-2026: A 74-Year-Old Man with Dyspnea, Proximal Muscle Weakness, and Hypoxemia — NEJM Clinical Medicine
A 74-year-old man with myasthenia gravis was evaluated for dyspnea, proximal muscle weakness, hypoxemia, and a painful tongue lesion. Medications included prednisone and mycophenolate mofetil. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Placement of a Catheter for Acute Peritoneal Dialysis — NEJM Clinical Medicine
This video demonstrates how to insert a catheter for emergency peritoneal dialysis in adults with a technique created specifically for environments that may have limited access to resources.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Crew Resource Management — Navigating AI’s Automation Paradox — NEJM Clinical Medicine
The more capable an AI copilot appears, the more likely clinicians are to offload tasks to it, eroding skills required for detecting its errors. CRM can help overcome this “automation paradox.”Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Drug-Induced Subacute Cutaneous Lupus Erythematosus — NEJM Clinical Medicine
A 73-year-old woman with rheumatoid arthritis and a 10-month history of pantoprazole therapy presented with skin lesions on her torso. Annular polycyclic lesions were observed on her upper back.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Mucolytics in Respiratory Failure — A MARCH Forward — NEJM Clinical Medicine
In patients with acute respiratory failure, difficulty managing respiratory secretions may contribute to adverse outcomes.1 Airway mucus is a multilayered substance consisting of a viscoelastic glycoprotein gel, a liquid layer, and a thin layer of surfactant.2 Mucus is cleared from the airway primarily by the action...…
Severe Plasmodium falciparum Malaria — NEJM Clinical Medicine
An 82-year-old man was brought to the ED after being “found down.” One week earlier, he had returned from a 1-month visit to Chad. A peripheral-blood smear showed ring-form trophozoites within erythrocytes.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
The Broader Dangers of Abandoning SGM Health Research — NEJM Clinical Medicine
When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
No to Azithromycin for Preschoolers with Acute Wheezing in the Emergency Department — NEJM Allergy-Immunology
Acute wheezing attacks are common in preschool-age children. These attacks lead to impaired quality of life1 and are associated with trajectories of poor lung function that may be lifelong, especially in children who are exposed to tobacco smoke and have allergic sensitization.2 Despite increased focus on...Fonte: NEJM…
Survodutide Once Weekly for the Treatment of Adults with Obesity — NEJM Clinical Medicine
In a phase 3 trial involving adults with obesity but without diabetes, the glucagon receptor–GLP-1 receptor dual agonist survodutide led to significantly greater reductions in body weight than placebo.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Drug-Induced Subacute Cutaneous Lupus Erythematosus — NEJM Allergy-Immunology
A 73-year-old woman with rheumatoid arthritis and a 10-month history of pantoprazole therapy presented with skin lesions on her torso. Annular polycyclic lesions were observed on her upper back.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Carbocisteine or Hypertonic Saline for Acute Respiratory Failure — NEJM Clinical Medicine
Among critically ill adults with acute respiratory failure, neither carbocisteine nor hypertonic saline reduced the duration of mechanical ventilation, and each strategy was associated with harm.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Myeloproliferative Neoplasms — NEJM Allergy-Immunology
This review summarizes the pathogenesis and treatment of myeloproliferative neoplasms, highlighting the role of driver mutations, inflammation, and emerging targeted therapies that may achieve durable disease modification.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
The Broader Dangers of Abandoning SGM Health Research — NEJM Cardiology
When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.Fonte: NEJM Cardiology — Categoria: medical_journals
Jaccoud’s Arthropathy — NEJM Clinical Medicine
A woman presented with a 2-year history of pain, swelling, and stiffness in the wrists and fingers. Deformities were noted in her fingers and thumbs. When the hands were clenched into fists, the deformities resolved, as shown in a video.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Drug-Induced Subacute Cutaneous Lupus Erythematosus — NEJM Rheumatology
A 73-year-old woman with rheumatoid arthritis and a 10-month history of pantoprazole therapy presented with skin lesions on her torso. Annular polycyclic lesions were observed on her upper back.Fonte: NEJM Rheumatology — Categoria: medical_journals
The Broader Dangers of Abandoning SGM Health Research — NEJM Health policy
When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.Fonte: NEJM Health policy — Categoria: medical_journals
Marijuana Rescheduling — A Game Changer for Research? — NEJM Health policy
A proposed reclassification of medical marijuana products as Schedule III drugs would address only two of the three key barriers to research on marijuana’s safety and effectiveness for various indications.Fonte: NEJM Health policy — Categoria: medical_journals
Marijuana Rescheduling — A Game Changer for Research? — NEJM Neurology-neurosurgery
A proposed reclassification of medical marijuana products as Schedule III drugs would address only two of the three key barriers to research on marijuana’s safety and effectiveness for various indications.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Marijuana Rescheduling — A Game Changer for Research? — NEJM Hematology-oncology
A proposed reclassification of medical marijuana products as Schedule III drugs would address only two of the three key barriers to research on marijuana’s safety and effectiveness for various indications.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Drug-Induced Subacute Cutaneous Lupus Erythematosus — NEJM Allergy-Immunology
A 73-year-old woman with rheumatoid arthritis and a 10-month history of pantoprazole therapy presented with skin lesions on her torso. Annular polycyclic lesions were observed on her upper back.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
The Broader Dangers of Abandoning SGM Health Research — NEJM Cardiology
When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.Fonte: NEJM Cardiology — Categoria: medical_journals
Drug-Induced Subacute Cutaneous Lupus Erythematosus — NEJM Clinical Medicine
A 73-year-old woman with rheumatoid arthritis and a 10-month history of pantoprazole therapy presented with skin lesions on her torso. Annular polycyclic lesions were observed on her upper back.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
The Broader Dangers of Abandoning SGM Health Research — NEJM Clinical Medicine
When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Drug-Induced Subacute Cutaneous Lupus Erythematosus — NEJM Dermatology
A 73-year-old woman with rheumatoid arthritis and a 10-month history of pantoprazole therapy presented with skin lesions on her torso. Annular polycyclic lesions were observed on her upper back.Fonte: NEJM Dermatology — Categoria: medical_journals
The Broader Dangers of Abandoning SGM Health Research — NEJM Endocrinology
When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.Fonte: NEJM Endocrinology — Categoria: medical_journals
Selpercatinib in Early-Stage RET Fusion–Positive Non–Small-Cell Lung Cancer — NEJM Pulmonary-critical-care
Among patients with RET fusion–positive non–small-cell lung cancer, adjuvant selpercatinib led to longer event-free survival than placebo. Adverse events of grade 3 or higher included elevated liver-enzyme levels.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica — NEJM Rheumatology
Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone.Fonte: NEJM Rheumatology — Categoria: medical_journals
Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting — NEJM Rheumatology
Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rhe…
Gene Editing, Peroxisomal Disorders, and Treatments for Rare Disease — NEJM Pediatrics
This article describes gene editing in a mouse model of a peroxisomal disorder, as well as the broader landscape, including regulation, of the treatment of rare genetic disease through gene editing.Fonte: NEJM Pediatrics — Categoria: medical_journals
Leucovorin Dispensing to U.S. Children in 2025 — NEJM Pediatrics
A study noted a sharp increase in leucovorin prescriptions dispensed to children (≤17 years of age) after a plan was announced to update the FDA drug label to include cerebral folate deficiency, which may include autism symptoms.Fonte: NEJM Pediatrics — Categoria: medical_journals
PRAME-Specific T-Cell Therapy in Advanced Pediatric Nephroblastoma — NEJM Pediatrics
In a child with advanced nephroblastoma, T-cell therapy targeting preferentially expressed antigen in melanoma led to a 69% tumor reduction, with molecular, metabolic, and histologic evidence of complete remission at 200 days.Fonte: NEJM Pediatrics — Categoria: medical_journals
PRAME-Specific T-Cell Therapy in Advanced Pediatric Nephroblastoma — NEJM Nephrology
In a child with advanced nephroblastoma, T-cell therapy targeting preferentially expressed antigen in melanoma led to a 69% tumor reduction, with molecular, metabolic, and histologic evidence of complete remission at 200 days.Fonte: NEJM Nephrology — Categoria: medical_journals
Last Man Running — NEJM Neurology-neurosurgery
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Leucovorin Dispensing to U.S. Children in 2025 — NEJM Neurology-neurosurgery
A study noted a sharp increase in leucovorin prescriptions dispensed to children (≤17 years of age) after a plan was announced to update the FDA drug label to include cerebral folate deficiency, which may include autism symptoms.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Case 23-2026: A 28-Year-Old Woman with Nausea, Dizziness, and Metabolic Acidosis — NEJM Nephrology
A 28-year-old woman presented to the emergency department because of abdominal pain, nausea, vomiting, and dizziness. The body-mass index was 18, and the anion gap was elevated. A diagnosis was made.Fonte: NEJM Nephrology — Categoria: medical_journals
Resistance, Strategic Compromise, or Complicity? Physicians’ Choices under Ethical Pressure — NEJM Health policy
Faced with pressure to violate professional ethics, how can physicians tell the difference between a strategic compromise and complicity in undermining science or harming patients and public health?Fonte: NEJM Health policy — Categoria: medical_journals
Evidence-Based Tobacco-Cessation Strategies for Low- and Middle-Income Countries — NEJM Health policy
This review summarizes tobacco-cessation strategies in low- and middle-income countries, with emphasis on population-level interventions, subsidized pharmacotherapy, and systemwide integration to expand access to treatment.Fonte: NEJM Health policy — Categoria: medical_journals
Last Man Running — NEJM Health policy
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.Fonte: NEJM Health policy — Categoria: medical_journals
Leucovorin Dispensing to U.S. Children in 2025 — NEJM Health policy
A study noted a sharp increase in leucovorin prescriptions dispensed to children (≤17 years of age) after a plan was announced to update the FDA drug label to include cerebral folate deficiency, which may include autism symptoms.Fonte: NEJM Health policy — Categoria: medical_journals
Rethinking the Role of Pay for Performance in Federal Health Care Quality Programs — NEJM Health policy
Core elements of the pay-for-performance approach have inherent shortcomings. Achieving meaningful quality improvement at scale may require rethinking this paradigm.Fonte: NEJM Health policy — Categoria: medical_journals
Talquetamab–Daratumumab in Relapsed or Refractory Myeloma — NEJM Hematology-oncology
Talquetamab–daratumumab, with or without pomalidomide, led to longer progression-free survival than daratumumab-based standard care in relapsed or refractory myeloma. More than 75% of patients had grade 3 or higher adverse events.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Selpercatinib in Early-Stage RET Fusion–Positive Non–Small-Cell Lung Cancer — NEJM Hematology-oncology
Among patients with RET fusion–positive non–small-cell lung cancer, adjuvant selpercatinib led to longer event-free survival than placebo. Adverse events of grade 3 or higher included elevated liver-enzyme levels.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Disseminated Fusariosis — NEJM Hematology-oncology
A 61-year-old man with prolonged neutropenia after chemotherapy for AML was evaluated for persistent fever despite antimicrobial therapy. Physical examination was notable for a skin macule with central necrosis on the chest.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Warthin Tumors — NEJM Hematology-oncology
A 55-year-old man with a smoking history of 10 pack-years presented with 2 years of an enlarging, painless lump below his right ear. A previously unnoticed smaller mass in the left parotid gland was seen on examination.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
PRAME-Specific T-Cell Therapy in Advanced Pediatric Nephroblastoma — NEJM Hematology-oncology
In a child with advanced nephroblastoma, T-cell therapy targeting preferentially expressed antigen in melanoma led to a 69% tumor reduction, with molecular, metabolic, and histologic evidence of complete remission at 200 days.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Disseminated Fusariosis — NEJM Infectious diseases
A 61-year-old man with prolonged neutropenia after chemotherapy for AML was evaluated for persistent fever despite antimicrobial therapy. Physical examination was notable for a skin macule with central necrosis on the chest.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Long-Acting Treatment and Advanced HIV Disease — Addressing a Public Health Priority — NEJM Infectious diseases
Without deliberate efforts to evaluate long-acting injectable ART in the populations that need these therapies most, their benefits may accrue primarily to people who are well served by existing systems.Fonte: NEJM Infectious diseases — Categoria: medical_journals
iEvac-Z, an Inactivated Ebola Vaccine — Phase 1 Study in Japan — NEJM Infectious diseases
Ebola virus continues to be a global threat. In a phase 1 study, an inactivated Ebola virus vaccine was tested in healthy volunteers for safety and immunogenicity.Fonte: NEJM Infectious diseases — Categoria: medical_journals
A Regional Measles Outbreak — South Carolina, 2025–2026 — NEJM Infectious diseases
In South Carolina, 997 measles cases occurred in the reported outbreak. In one health care system, 81 cases were identified. Most were in unvaccinated persons; 13 persons were hospitalized, and 2 had measles encephalitis.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Long-Acting Treatment and Advanced HIV Disease — Addressing a Public Health Priority — NEJM Health policy
Without deliberate efforts to evaluate long-acting injectable ART in the populations that need these therapies most, their benefits may accrue primarily to people who are well served by existing systems.Fonte: NEJM Health policy — Categoria: medical_journals
In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia — NEJM Genetics
The authors report reductions in PCSK9 and LDL cholesterol levels and no dose-limiting toxic effects in persons with hypercholesterolemia treated with VERVE-102, a base editor targeting PCSK9.Fonte: NEJM Genetics — Categoria: medical_journals
Gene Editing, Peroxisomal Disorders, and Treatments for Rare Disease — NEJM Genetics
This article describes gene editing in a mouse model of a peroxisomal disorder, as well as the broader landscape, including regulation, of the treatment of rare genetic disease through gene editing.Fonte: NEJM Genetics — Categoria: medical_journals
A New Approach to Lowering LDL Cholesterol — NEJM Genetics
The pioneering work of Vafai and colleagues, reported in this issue of the Journal,1 paves the way for a new type of low-density lipoprotein (LDL) cholesterol–lowering therapy called VERVE-102: a therapy that appears to lower LDL cholesterol levels enough to reduce the risk of atherosclerotic cardiovascular...Fonte: NE…
Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica — NEJM Geriatrics-Aging
Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting — NEJM Geriatrics-Aging
Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rhe…
Last Man Running — NEJM Geriatrics-Aging
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Case 23-2026: A 28-Year-Old Woman with Nausea, Dizziness, and Metabolic Acidosis — NEJM Emergency Medicine
A 28-year-old woman presented to the emergency department because of abdominal pain, nausea, vomiting, and dizziness. The body-mass index was 18, and the anion gap was elevated. A diagnosis was made.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Gene Editing, Peroxisomal Disorders, and Treatments for Rare Disease — NEJM Gastroenterology
This article describes gene editing in a mouse model of a peroxisomal disorder, as well as the broader landscape, including regulation, of the treatment of rare genetic disease through gene editing.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Leucovorin Dispensing to U.S. Children in 2025 — NEJM Gastroenterology
A study noted a sharp increase in leucovorin prescriptions dispensed to children (≤17 years of age) after a plan was announced to update the FDA drug label to include cerebral folate deficiency, which may include autism symptoms.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Disseminated Fusariosis — NEJM Dermatology
A 61-year-old man with prolonged neutropenia after chemotherapy for AML was evaluated for persistent fever despite antimicrobial therapy. Physical examination was notable for a skin macule with central necrosis on the chest.Fonte: NEJM Dermatology — Categoria: medical_journals
Evidence-Based Tobacco-Cessation Strategies for Low- and Middle-Income Countries — NEJM Clinical Medicine
This review summarizes tobacco-cessation strategies in low- and middle-income countries, with emphasis on population-level interventions, subsidized pharmacotherapy, and systemwide integration to expand access to treatment.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica — NEJM Clinical Medicine
Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting — NEJM Clinical Medicine
Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rhe…
Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica — NEJM Allergy-Immunology
Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Resistance, Strategic Compromise, or Complicity? Physicians’ Choices under Ethical Pressure — NEJM Clinical Medicine
Faced with pressure to violate professional ethics, how can physicians tell the difference between a strategic compromise and complicity in undermining science or harming patients and public health?Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Warthin Tumors — NEJM Clinical Medicine
A 55-year-old man with a smoking history of 10 pack-years presented with 2 years of an enlarging, painless lump below his right ear. A previously unnoticed smaller mass in the left parotid gland was seen on examination.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Disseminated Fusariosis — NEJM Clinical Medicine
A 61-year-old man with prolonged neutropenia after chemotherapy for AML was evaluated for persistent fever despite antimicrobial therapy. Physical examination was notable for a skin macule with central necrosis on the chest.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
A New Approach to Lowering LDL Cholesterol — NEJM Cardiology
The pioneering work of Vafai and colleagues, reported in this issue of the Journal,1 paves the way for a new type of low-density lipoprotein (LDL) cholesterol–lowering therapy called VERVE-102: a therapy that appears to lower LDL cholesterol levels enough to reduce the risk of atherosclerotic cardiovascular...Fonte: NE…
In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia — NEJM Cardiology
The authors report reductions in PCSK9 and LDL cholesterol levels and no dose-limiting toxic effects in persons with hypercholesterolemia treated with VERVE-102, a base editor targeting PCSK9.Fonte: NEJM Cardiology — Categoria: medical_journals
Last Man Running — NEJM Cardiology
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.Fonte: NEJM Cardiology — Categoria: medical_journals
Leucovorin Dispensing to U.S. Children in 2025 — NEJM Clinical Medicine
A study noted a sharp increase in leucovorin prescriptions dispensed to children (≤17 years of age) after a plan was announced to update the FDA drug label to include cerebral folate deficiency, which may include autism symptoms.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting — NEJM Allergy-Immunology
Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rhe…
Rethinking the Role of Pay for Performance in Federal Health Care Quality Programs — NEJM Clinical Medicine
Core elements of the pay-for-performance approach have inherent shortcomings. Achieving meaningful quality improvement at scale may require rethinking this paradigm.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Case 23-2026: A 28-Year-Old Woman with Nausea, Dizziness, and Metabolic Acidosis — NEJM Clinical Medicine
A 28-year-old woman presented to the emergency department because of abdominal pain, nausea, vomiting, and dizziness. The body-mass index was 18, and the anion gap was elevated. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Last Man Running — NEJM Geriatrics-Aging
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Resistance, Strategic Compromise, or Complicity? Physicians’ Choices under Ethical Pressure — NEJM Health policy
Faced with pressure to violate professional ethics, how can physicians tell the difference between a strategic compromise and complicity in undermining science or harming patients and public health?Fonte: NEJM Health policy — Categoria: medical_journals
Last Man Running — NEJM Health policy
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.Fonte: NEJM Health policy — Categoria: medical_journals
Rethinking the Role of Pay for Performance in Federal Health Care Quality Programs — NEJM Health policy
Core elements of the pay-for-performance approach have inherent shortcomings. Achieving meaningful quality improvement at scale may require rethinking this paradigm.Fonte: NEJM Health policy — Categoria: medical_journals
Warthin Tumors — NEJM Hematology-oncology
A 55-year-old man with a smoking history of 10 pack-years presented with 2 years of an enlarging, painless lump below his right ear. A previously unnoticed smaller mass in the left parotid gland was seen on examination.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Last Man Running — NEJM Neurology-neurosurgery
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Last Man Running — NEJM Cardiology
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.Fonte: NEJM Cardiology — Categoria: medical_journals
Resistance, Strategic Compromise, or Complicity? Physicians’ Choices under Ethical Pressure — NEJM Clinical Medicine
Faced with pressure to violate professional ethics, how can physicians tell the difference between a strategic compromise and complicity in undermining science or harming patients and public health?Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Warthin Tumors — NEJM Clinical Medicine
A 55-year-old man with a smoking history of 10 pack-years presented with 2 years of an enlarging, painless lump below his right ear. A previously unnoticed smaller mass in the left parotid gland was seen on examination.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Rethinking the Role of Pay for Performance in Federal Health Care Quality Programs — NEJM Clinical Medicine
Core elements of the pay-for-performance approach have inherent shortcomings. Achieving meaningful quality improvement at scale may require rethinking this paradigm.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Type 1 Autoimmune Pancreatitis — NEJM Rheumatology
A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely enlarged pancreas with a capsule-like rim. Serum levels of IgG4 were elevated.Fonte: NEJM Rheumatology — Categoria: medical_journals
Obstructive Hypertrophic Cardiomyopathy — NEJM Surgery
A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent imaging (shown in a video) showed near-complete apposition of the ventricular walls during systole.Fonte: NEJM Surgery — Categoria: public_health
Conservative Oxygen for Unresponsive Patients after Cardiac Arrest — NEJM Pulmonary-critical-care
Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Syncope — NEJM Pulmonary-critical-care
This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Oxygen Targets after Cardiac Arrest — A LOGICAL Finding — NEJM Pulmonary-critical-care
In unresponsive patients after cardiac arrest, a complex pathophysiological response including potential brain injury, myocardial dysfunction, and systemic ischemia–reperfusion injury is at play, in addition to the challenges of the underlying cause of cardiac arrest.1 This complex and unique, but heterogeneous, conste…
Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD — NEJM Pediatrics
In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.Fonte: NEJM Pediatrics — Categoria: medical_journals
Perioperative Apalutamide in High-Risk Localized Prostate Cancer — NEJM Hematology-oncology
In high-risk localized prostate cancer, ADT plus apalutamide led to a pathological complete response or minimal residual disease and 5-year metastasis-free survival in a greater percentage of patients than ADT plus placebo.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Consumed with Inflammation — NEJM Hematology-oncology
A 60-year-old woman with stage II triple-negative breast cancer presented to the ED with a weeklong history of fevers, rigors, malaise, nonproductive cough, and nausea.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
A Watershed Moment in the Perioperative Treatment of Prostate Cancer — NEJM Hematology-oncology
Current curative-intent management of high-risk localized prostate cancer (nonmetastatic prostate cancer with extraprostatic extension or seminal-vesicle invasion, a histologic Gleason score of ≥8 [on a scale from 6 to 10, with higher scores indicating more aggressive disease], or a serum prostate-specific antigen leve…
Ebola at 50 — Lessons for Outbreak Response and Preparedness — NEJM Infectious diseases
An accurate history of Ebola begins with partnerships, including those between responders and the populations they serve. One of its key lessons is that equity must be integral to outbreak preparedness.Fonte: NEJM Infectious diseases — Categoria: medical_journals
The Social Contract of Bundibugyo Ebola Isolation — NEJM Infectious diseases
The lack of vaccines and disease-specific therapeutics for Bundibugyo Ebola has dramatically affected the community’s perception of Ebola treatment centers. In this context, trust becomes critical.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Cross-Reactive Bundibugyo Antibody Responses after Receipt of Licensed Ebola Vaccines — NEJM Infectious diseases
The Bundibugyo virus outbreak in the DRC and Uganda has focused concern on potential countermeasures. Investigators assessed cross-reactive immune responses in serum obtained during previous Ebola vaccine trials.Fonte: NEJM Infectious diseases — Categoria: medical_journals
The Inequality–Pandemic Cycle — Rethinking Preparedness — NEJM Infectious diseases
Increasing pandemic frequency and increasing economic inequality are creating a self-reinforcing cycle. What’s needed is therefore a new, inequality-informed approach to pandemic preparedness.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Finerenone in Persons with Chronic Kidney Disease without Diabetes — NEJM Nephrology
In adults without diabetes who had chronic kidney disease, the nonsteroidal mineralocorticoid receptor antagonist finerenone led to a slower decrease in the estimate glomerular filtration rate than placebo over 32 months.Fonte: NEJM Nephrology — Categoria: medical_journals
Clinical Characteristics of Patients Infected with Bundibugyo Virus, DRC 2026 — NEJM Infectious diseases
Bundibugyo virus, a filovirus, is currently spreading in the Democratic Republic of Congo. This report presents early data on symptoms and illness severity as well as diagnostic challenges.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Mineralocorticoid Receptor Antagonism — FINDing Another Benefit — NEJM Nephrology
Aldosterone plays a critical role in the homeostasis of blood pressure and volume by engaging mineralocorticoid receptors in the kidneys, heart, and other organs.1 However, overactivation of mineralocorticoid receptors contributes to the pathogenesis of chronic kidney disease (CKD) and heart failure, in part by causing…
Conservative Oxygen for Unresponsive Patients after Cardiac Arrest — NEJM Neurology-neurosurgery
Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Syncope — NEJM Neurology-neurosurgery
This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Oxygen Targets after Cardiac Arrest — A LOGICAL Finding — NEJM Neurology-neurosurgery
In unresponsive patients after cardiac arrest, a complex pathophysiological response including potential brain injury, myocardial dysfunction, and systemic ischemia–reperfusion injury is at play, in addition to the challenges of the underlying cause of cardiac arrest.1 This complex and unique, but heterogeneous, conste…
The Social Contract of Bundibugyo Ebola Isolation — NEJM Health policy
The lack of vaccines and disease-specific therapeutics for Bundibugyo Ebola has dramatically affected the community’s perception of Ebola treatment centers. In this context, trust becomes critical.Fonte: NEJM Health policy — Categoria: medical_journals
Doctor’s Dirty Little Secret — The Cost of Silence — NEJM Health policy
How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?Fonte: NEJM Health policy — Categoria: medical_journals
Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD — NEJM Neurology-neurosurgery
In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
The Inequality–Pandemic Cycle — Rethinking Preparedness — NEJM Health policy
Increasing pandemic frequency and increasing economic inequality are creating a self-reinforcing cycle. What’s needed is therefore a new, inequality-informed approach to pandemic preparedness.Fonte: NEJM Health policy — Categoria: medical_journals
Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD — NEJM Genetics
In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.Fonte: NEJM Genetics — Categoria: medical_journals
Obstructive Hypertrophic Cardiomyopathy — NEJM Clinical Medicine
A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent imaging (shown in a video) showed near-complete apposition of the ventricular walls during systole.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Sirolimus-Eluting Technology for the Treatment of Peripheral Artery Disease — NEJM Cardiology
Patients with advanced peripheral artery disease often undergo either surgical or endovascular revascularization for the treatment of lifestyle-limiting claudication or nonhealing lower-limb wounds. Major limitations of endovascular intervention include the high incidence of restenosis and the need for repeat intervent…
Conservative Oxygen for Unresponsive Patients after Cardiac Arrest — NEJM Cardiology
Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy.Fonte: NEJM Cardiology — Categoria: medical_journals
Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD — NEJM Cardiology
In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.Fonte: NEJM Cardiology — Categoria: medical_journals
Oxygen Targets after Cardiac Arrest — A LOGICAL Finding — NEJM Cardiology
In unresponsive patients after cardiac arrest, a complex pathophysiological response including potential brain injury, myocardial dysfunction, and systemic ischemia–reperfusion injury is at play, in addition to the challenges of the underlying cause of cardiac arrest.1 This complex and unique, but heterogeneous, conste…
Syncope — NEJM Emergency Medicine
This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Conservative Oxygen for Unresponsive Patients after Cardiac Arrest — NEJM Clinical Medicine
Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Doctor’s Dirty Little Secret — The Cost of Silence — NEJM Emergency Medicine
How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?Fonte: NEJM Emergency Medicine — Categoria: medical_journals
The Social Contract of Bundibugyo Ebola Isolation — NEJM Emergency Medicine
The lack of vaccines and disease-specific therapeutics for Bundibugyo Ebola has dramatically affected the community’s perception of Ebola treatment centers. In this context, trust becomes critical.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Oxygen Targets after Cardiac Arrest — A LOGICAL Finding — NEJM Emergency Medicine
In unresponsive patients after cardiac arrest, a complex pathophysiological response including potential brain injury, myocardial dysfunction, and systemic ischemia–reperfusion injury is at play, in addition to the challenges of the underlying cause of cardiac arrest.1 This complex and unique, but heterogeneous, conste…
Mineralocorticoid Receptor Antagonism — FINDing Another Benefit — NEJM Endocrinology
Aldosterone plays a critical role in the homeostasis of blood pressure and volume by engaging mineralocorticoid receptors in the kidneys, heart, and other organs.1 However, overactivation of mineralocorticoid receptors contributes to the pathogenesis of chronic kidney disease (CKD) and heart failure, in part by causing…
Type 1 Autoimmune Pancreatitis — NEJM Gastroenterology
A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely enlarged pancreas with a capsule-like rim. Serum levels of IgG4 were elevated.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Consumed with Inflammation — NEJM Clinical Medicine
A 60-year-old woman with stage II triple-negative breast cancer presented to the ED with a weeklong history of fevers, rigors, malaise, nonproductive cough, and nausea.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Conservative Oxygen for Unresponsive Patients after Cardiac Arrest — NEJM Emergency Medicine
Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Finerenone in Persons with Chronic Kidney Disease without Diabetes — NEJM Cardiology
In adults without diabetes who had chronic kidney disease, the nonsteroidal mineralocorticoid receptor antagonist finerenone led to a slower decrease in the estimate glomerular filtration rate than placebo over 32 months.Fonte: NEJM Cardiology — Categoria: medical_journals
Mineralocorticoid Receptor Antagonism — FINDing Another Benefit — NEJM Clinical Medicine
Aldosterone plays a critical role in the homeostasis of blood pressure and volume by engaging mineralocorticoid receptors in the kidneys, heart, and other organs.1 However, overactivation of mineralocorticoid receptors contributes to the pathogenesis of chronic kidney disease (CKD) and heart failure, in part by causing…
Finerenone in Persons with Chronic Kidney Disease without Diabetes — NEJM Clinical Medicine
In adults without diabetes who had chronic kidney disease, the nonsteroidal mineralocorticoid receptor antagonist finerenone led to a slower decrease in the estimate glomerular filtration rate than placebo over 32 months.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Type 1 Autoimmune Pancreatitis — NEJM Clinical Medicine
A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely enlarged pancreas with a capsule-like rim. Serum levels of IgG4 were elevated.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Mineralocorticoid Receptor Antagonism — FINDing Another Benefit — NEJM Cardiology
Aldosterone plays a critical role in the homeostasis of blood pressure and volume by engaging mineralocorticoid receptors in the kidneys, heart, and other organs.1 However, overactivation of mineralocorticoid receptors contributes to the pathogenesis of chronic kidney disease (CKD) and heart failure, in part by causing…
Oxygen Targets after Cardiac Arrest — A LOGICAL Finding — NEJM Clinical Medicine
In unresponsive patients after cardiac arrest, a complex pathophysiological response including potential brain injury, myocardial dysfunction, and systemic ischemia–reperfusion injury is at play, in addition to the challenges of the underlying cause of cardiac arrest.1 This complex and unique, but heterogeneous, conste…
Obstructive Hypertrophic Cardiomyopathy — NEJM Cardiology
A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent imaging (shown in a video) showed near-complete apposition of the ventricular walls during systole.Fonte: NEJM Cardiology — Categoria: medical_journals
Fast Track in Internal Medicine Residency — NEJM Clinical Medicine
This feature about the internal medicine residency track offers a case vignette accompanied by two essays, one recommending offering the option of a 2-year “fast-track” program and the other supporting maintaining the current 3-year residency program.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Syncope — NEJM Cardiology
This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.Fonte: NEJM Cardiology — Categoria: medical_journals
Doctor’s Dirty Little Secret — The Cost of Silence — NEJM Clinical Medicine
How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease — NEJM Cardiology
Among patients with infrainguinal artery disease who were undergoing angioplasty, the risk of major adverse limb events at 1 year was lower with sirolimus-coated balloons than with uncoated balloons, and mortality was similar.Fonte: NEJM Cardiology — Categoria: medical_journals
Syncope — NEJM Geriatrics-Aging
This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Syncope — NEJM Clinical Medicine
This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Consumed with Inflammation — NEJM Allergy-Immunology
A 60-year-old woman with stage II triple-negative breast cancer presented to the ED with a weeklong history of fevers, rigors, malaise, nonproductive cough, and nausea.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Type 1 Autoimmune Pancreatitis — NEJM Allergy-Immunology
A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely enlarged pancreas with a capsule-like rim. Serum levels of IgG4 were elevated.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Obstructive Hypertrophic Cardiomyopathy — NEJM Surgery
A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent imaging (shown in a video) showed near-complete apposition of the ventricular walls during systole.Fonte: NEJM Surgery — Categoria: public_health
Doctor’s Dirty Little Secret — The Cost of Silence — NEJM Health policy
How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?Fonte: NEJM Health policy — Categoria: medical_journals
Obstructive Hypertrophic Cardiomyopathy — NEJM Cardiology
A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent imaging (shown in a video) showed near-complete apposition of the ventricular walls during systole.Fonte: NEJM Cardiology — Categoria: medical_journals
Obstructive Hypertrophic Cardiomyopathy — NEJM Clinical Medicine
A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent imaging (shown in a video) showed near-complete apposition of the ventricular walls during systole.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Doctor’s Dirty Little Secret — The Cost of Silence — NEJM Clinical Medicine
How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Doctor’s Dirty Little Secret — The Cost of Silence — NEJM Emergency Medicine
How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?Fonte: NEJM Emergency Medicine — Categoria: medical_journals
T-Cell Engager–Mediated HLA Antibody Depletion before Kidney Transplantation — NEJM Surgery
A patient with high-level HLA sensitization received T-cell engager–mediated HLA antibody depletion with teclistamab, a bispecific B-cell maturation antigen–directed CD3 T-cell engager, which enabled kidney transplantation.Fonte: NEJM Surgery — Categoria: public_health
Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain — NEJM Surgery
The selective NaV1.8 inhibitor LTG-001 led to significantly greater reductions in pain scores than placebo over the course of 48 hours among patients who had moderate or severe pain after abdominoplasty.Fonte: NEJM Surgery — Categoria: public_health
Cross-Correction in HSC Gene Therapy for Metachromatic Leukodystrophy — NEJM Neurology-neurosurgery
This study supports enzymatic cross-correction of neurons and oligodendrocytes by atidarsagene autotemcel, a gene therapy that prevents or slows neurodegeneration in children with early-onset metachromatic leukodystrophy.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Braking Bad News — NEJM Neurology-neurosurgery
When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Pregnancies in Patients with Autoimmune Disease Receiving CAR T-Cell Therapy — NEJM Obstetrics-gynecology
Among 14 pregnancies in 13 patients with autoimmune disease who had undergone CAR T-cell therapy, early maternal and neonatal outcomes appeared reassuring, with no disease relapses reported and 8 healthy infants born to date.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain — NEJM Obstetrics-gynecology
The selective NaV1.8 inhibitor LTG-001 led to significantly greater reductions in pain scores than placebo over the course of 48 hours among patients who had moderate or severe pain after abdominoplasty.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Iptacopan in IgA Nephropathy — Final 24-Month Data — NEJM Pediatrics
Alternative complement pathway overactivation contributes to IgA nephropathy. In a placebo-controlled trial, iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy.Fonte: NEJM Pediatrics — Categoria: medical_journals
Medical Standards by Federal Fiat — NEJM Pediatrics
The Trump administration’s legal theories about gender-affirming care, if accepted, could shift the equilibrium of medical decision making in the United States in important ways.Fonte: NEJM Pediatrics — Categoria: medical_journals
Cross-Correction in HSC Gene Therapy for Metachromatic Leukodystrophy — NEJM Pediatrics
This study supports enzymatic cross-correction of neurons and oligodendrocytes by atidarsagene autotemcel, a gene therapy that prevents or slows neurodegeneration in children with early-onset metachromatic leukodystrophy.Fonte: NEJM Pediatrics — Categoria: medical_journals
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Pulmonary-critical-care
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Iptacopan in IgA Nephropathy — Final 24-Month Data — NEJM Nephrology
Alternative complement pathway overactivation contributes to IgA nephropathy. In a placebo-controlled trial, iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy.Fonte: NEJM Nephrology — Categoria: medical_journals
T-Cell Engager–Mediated HLA Antibody Depletion before Kidney Transplantation — NEJM Nephrology
A patient with high-level HLA sensitization received T-cell engager–mediated HLA antibody depletion with teclistamab, a bispecific B-cell maturation antigen–directed CD3 T-cell engager, which enabled kidney transplantation.Fonte: NEJM Nephrology — Categoria: medical_journals
Milwaukee Shoulder Syndrome — NEJM Rheumatology
A 45-year-old man presented with a 2-month history of worsening pain and swelling in his right shoulder. A radiograph showed destruction of the humeral head with a free-floating humeral diaphysis.Fonte: NEJM Rheumatology — Categoria: medical_journals
Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain — NEJM Neurology-neurosurgery
The selective NaV1.8 inhibitor LTG-001 led to significantly greater reductions in pain scores than placebo over the course of 48 hours among patients who had moderate or severe pain after abdominoplasty.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
The Paradox of Medical Aid in Dying — NEJM Geriatrics-Aging
As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
The Paradox of Medical Aid in Dying — NEJM Health policy
As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.Fonte: NEJM Health policy — Categoria: medical_journals
Products That Pose Health Risks — Can Litigation Protect Us When Government Fails? — NEJM Health policy
Recent lawsuits against social media companies, like past litigation against drug and tobacco manufacturers, show that when other branches of government fail to protect public health, the courts can help.Fonte: NEJM Health policy — Categoria: medical_journals
The Inequality–Pandemic Cycle — Rethinking Preparedness — NEJM Health policy
Increasing pandemic frequency and increasing economic inequality are creating a self-reinforcing cycle. What’s needed is therefore a new, inequality-informed approach to pandemic preparedness.Fonte: NEJM Health policy — Categoria: medical_journals
Medical Standards by Federal Fiat — NEJM Health policy
The Trump administration’s legal theories about gender-affirming care, if accepted, could shift the equilibrium of medical decision making in the United States in important ways.Fonte: NEJM Health policy — Categoria: medical_journals
Teclistamab in Multiple Myeloma with One to Three Previous Lines of Therapy — NEJM Hematology-oncology
In relapsed multiple myeloma, teclistamab improved 18-month progression-free survival as compared with standard therapy. Grade 3 or 4 infections were common; antimicrobial prophylaxis and immune globulin support were recommended.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
PARP and Androgen-Signaling Inhibition plus ADT in Metastatic Prostate Cancer — NEJM Hematology-oncology
In patients with metastatic prostate cancer with gene alterations, talazoparib–enzalutamide led to better progression-free survival outcomes than placebo–enzalutamide but with more serious adverse events.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Precision Intensification in Metastatic Prostate Cancer — NEJM Hematology-oncology
The treatment of advanced prostate cancer has undergone significant improvements, with two developments proven to be especially transformative. The first advance was the establishment of treatment intensification in patients with metastatic castration-sensitive prostate cancer (hereafter referred to as metastatic andro…
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Hematology-oncology
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Cross-Correction in HSC Gene Therapy for Metachromatic Leukodystrophy — NEJM Hematology-oncology
This study supports enzymatic cross-correction of neurons and oligodendrocytes by atidarsagene autotemcel, a gene therapy that prevents or slows neurodegeneration in children with early-onset metachromatic leukodystrophy.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Redefining Early Relapse in Multiple Myeloma — Time to Change the Rules — NEJM Hematology-oncology
The treatment landscape of multiple myeloma has undergone a profound transformation over the past two decades, driven by deeper insights into disease biology, refined patient stratification, the integration of new prognostic biomarkers, and sustained therapeutic innovation. Today, most patients receive proteasome inhib…
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Infectious diseases
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Case 22-2026: A 37-Year-Old Woman with Persistent Nasal Ulceration — NEJM Infectious diseases
A 37-year-old woman was evaluated for a 17-year history of unilateral nasal scabbing and bleeding. Nasal endoscopy showed marked, multifocal crusting and ulceration. A diagnosis was made.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Cross-Correction in HSC Gene Therapy for Metachromatic Leukodystrophy — NEJM Genetics
This study supports enzymatic cross-correction of neurons and oligodendrocytes by atidarsagene autotemcel, a gene therapy that prevents or slows neurodegeneration in children with early-onset metachromatic leukodystrophy.Fonte: NEJM Genetics — Categoria: medical_journals
The Inequality–Pandemic Cycle — Rethinking Preparedness — NEJM Infectious diseases
Increasing pandemic frequency and increasing economic inequality are creating a self-reinforcing cycle. What’s needed is therefore a new, inequality-informed approach to pandemic preparedness.Fonte: NEJM Infectious diseases — Categoria: medical_journals
iEvac-Z, an Inactivated Ebola Vaccine — Phase 1 Study in Japan — NEJM Infectious diseases
Ebola virus continues to be a global threat. In a phase 1 study, an inactivated Ebola virus vaccine was tested in healthy volunteers for safety and immunogenicity.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment — NEJM Infectious diseases
Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Iptacopan in IgA Nephropathy — Final 24-Month Data — NEJM Clinical Medicine
Alternative complement pathway overactivation contributes to IgA nephropathy. In a placebo-controlled trial, iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Milwaukee Shoulder Syndrome — NEJM Clinical Medicine
A 45-year-old man presented with a 2-month history of worsening pain and swelling in his right shoulder. A radiograph showed destruction of the humeral head with a free-floating humeral diaphysis.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain — NEJM Clinical Medicine
The selective NaV1.8 inhibitor LTG-001 led to significantly greater reductions in pain scores than placebo over the course of 48 hours among patients who had moderate or severe pain after abdominoplasty.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Braking Bad News — NEJM Clinical Medicine
When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
The Paradox of Medical Aid in Dying — NEJM Clinical Medicine
As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Pulsatile Liver in Severe Tricuspid Regurgitation — NEJM Clinical Medicine
A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Case 22-2026: A 37-Year-Old Woman with Persistent Nasal Ulceration — NEJM Clinical Medicine
A 37-year-old woman was evaluated for a 17-year history of unilateral nasal scabbing and bleeding. Nasal endoscopy showed marked, multifocal crusting and ulceration. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
T-Cell Engager–Mediated HLA Antibody Depletion before Kidney Transplantation — NEJM Clinical Medicine
A patient with high-level HLA sensitization received T-cell engager–mediated HLA antibody depletion with teclistamab, a bispecific B-cell maturation antigen–directed CD3 T-cell engager, which enabled kidney transplantation.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Medical Standards by Federal Fiat — NEJM Clinical Medicine
The Trump administration’s legal theories about gender-affirming care, if accepted, could shift the equilibrium of medical decision making in the United States in important ways.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain — NEJM Dermatology
The selective NaV1.8 inhibitor LTG-001 led to significantly greater reductions in pain scores than placebo over the course of 48 hours among patients who had moderate or severe pain after abdominoplasty.Fonte: NEJM Dermatology — Categoria: medical_journals
Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain — NEJM Emergency Medicine
The selective NaV1.8 inhibitor LTG-001 led to significantly greater reductions in pain scores than placebo over the course of 48 hours among patients who had moderate or severe pain after abdominoplasty.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Milwaukee Shoulder Syndrome — NEJM Emergency Medicine
A 45-year-old man presented with a 2-month history of worsening pain and swelling in his right shoulder. A radiograph showed destruction of the humeral head with a free-floating humeral diaphysis.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Pulsatile Liver in Severe Tricuspid Regurgitation — NEJM Cardiology
A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).Fonte: NEJM Cardiology — Categoria: medical_journals
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Cardiology
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Cardiology — Categoria: medical_journals
Iptacopan in IgA Nephropathy — Final 24-Month Data — NEJM Gastroenterology
Alternative complement pathway overactivation contributes to IgA nephropathy. In a placebo-controlled trial, iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Iptacopan in IgA Nephropathy — Final 24-Month Data — NEJM Allergy-Immunology
Alternative complement pathway overactivation contributes to IgA nephropathy. In a placebo-controlled trial, iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Pulsatile Liver in Severe Tricuspid Regurgitation — NEJM Gastroenterology
A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).Fonte: NEJM Gastroenterology — Categoria: medical_journals
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Allergy-Immunology
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
T-Cell Engager–Mediated HLA Antibody Depletion before Kidney Transplantation — NEJM Allergy-Immunology
A patient with high-level HLA sensitization received T-cell engager–mediated HLA antibody depletion with teclistamab, a bispecific B-cell maturation antigen–directed CD3 T-cell engager, which enabled kidney transplantation.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Pregnancies in Patients with Autoimmune Disease Receiving CAR T-Cell Therapy — NEJM Allergy-Immunology
Among 14 pregnancies in 13 patients with autoimmune disease who had undergone CAR T-cell therapy, early maternal and neonatal outcomes appeared reassuring, with no disease relapses reported and 8 healthy infants born to date.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Braking Bad News — NEJM Neurology-neurosurgery
When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Medical Standards by Federal Fiat — NEJM Pediatrics
The Trump administration’s legal theories about gender-affirming care, if accepted, could shift the equilibrium of medical decision making in the United States in important ways.Fonte: NEJM Pediatrics — Categoria: medical_journals
Pulsatile Liver in Severe Tricuspid Regurgitation — NEJM Gastroenterology
A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).Fonte: NEJM Gastroenterology — Categoria: medical_journals
The Paradox of Medical Aid in Dying — NEJM Geriatrics-Aging
As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
The Paradox of Medical Aid in Dying — NEJM Health policy
As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.Fonte: NEJM Health policy — Categoria: medical_journals
Medical Standards by Federal Fiat — NEJM Health policy
The Trump administration’s legal theories about gender-affirming care, if accepted, could shift the equilibrium of medical decision making in the United States in important ways.Fonte: NEJM Health policy — Categoria: medical_journals
Braking Bad News — NEJM Clinical Medicine
When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Pulsatile Liver in Severe Tricuspid Regurgitation — NEJM Clinical Medicine
A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Medical Standards by Federal Fiat — NEJM Clinical Medicine
The Trump administration’s legal theories about gender-affirming care, if accepted, could shift the equilibrium of medical decision making in the United States in important ways.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Pulsatile Liver in Severe Tricuspid Regurgitation — NEJM Cardiology
A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).Fonte: NEJM Cardiology — Categoria: medical_journals
The Paradox of Medical Aid in Dying — NEJM Clinical Medicine
As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Love and Death — NEJM Pulmonary-critical-care
In the ICU, a resident is surrounded by deaths, each one leaving him with a sense of emptiness. Then a Christmas tragedy highlights medicine’s privilege of bearing witness to love as well as death.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD — NEJM Pediatrics
In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.Fonte: NEJM Pediatrics — Categoria: medical_journals
Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract — NEJM Nephrology
In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infection, leading to a brain abscess.Fonte: NEJM Nephrology — Categoria: medical_journals
Neurocysticercosis — NEJM Neurology-neurosurgery
A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Case 21-2026: A 28-Year-Old Man with Headache and Vision Loss in the Right Eye — NEJM Neurology-neurosurgery
A 28-year-old man was admitted to the hospital because of monocular vision loss. Examination showed optic disk edema, and imaging revealed liver lesions and lymphadenopathy. A diagnosis was made.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract — NEJM Neurology-neurosurgery
In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infection, leading to a brain abscess.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD — NEJM Neurology-neurosurgery
In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy — NEJM Pediatrics
In this trial, among adolescents with obstructive hypertrophic cardiomyopathy, the cardiac myosin inhibitor mavacamten led to a significantly greater reduction in left ventricular outflow tract obstruction than placebo.Fonte: NEJM Pediatrics — Categoria: medical_journals
Antiretroviral Therapy — NEJM Infectious diseases
The choice of an ART regimen depends on potency, convenience, side effects, drug–drug interactions, patient factors, coexisting conditions, and access. Two- or three-drug once-daily oral regimens are recommended initially.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD — NEJM Genetics
In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.Fonte: NEJM Genetics — Categoria: medical_journals
When Celebrities Prescribe — Regulating Drug Promotion on the Internet — NEJM Health policy
Patient-targeted drug promotion has expanded beyond traditional advertising to the Internet, with social-media narratives shared by public figures. These new forms of marketing often evade regulatory scrutiny.Fonte: NEJM Health policy — Categoria: medical_journals
Crew Resource Management — Navigating AI’s Automation Paradox — NEJM Health policy
The more capable an AI copilot appears, the more likely clinicians are to offload tasks to it, eroding skills required for detecting its errors. CRM can help overcome this “automation paradox.”Fonte: NEJM Health policy — Categoria: medical_journals
Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer — NEJM Hematology-oncology
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Breaking the RAS Barrier in Pancreatic Cancer — NEJM Hematology-oncology
For decades, pancreatic ductal adenocarcinoma (PDAC) has been perhaps the clearest example of a cancer that is driven by a dominant oncogenic event yet is resistant to therapeutic exploitation. More than 90% of pancreatic cancers harbor activating RAS mutations, most commonly those involving KRAS codon 12,...Fonte: NEJ…
Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection — NEJM Infectious diseases
Observational evidence suggests that the four-component meningococcal B vaccine (4CMenB) may reduce gonorrhea risk. In this randomized trial, 4CMenB did not result in a lower incidence of N. gonorrhoeae infection than placebo.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Clinical Long-Read Genome Sequencing for Rare-Disease Diagnostics — NEJM Genetics
In 832 patients with rare genetic disease, a conclusive diagnosis was made for 160 patients (19.2%) with long-read genome sequencing and for 137 patients (16.5%) with standard-of-care testing.Fonte: NEJM Genetics — Categoria: medical_journals
Cross-Reactive Bundibugyo Antibody Responses after Receipt of Licensed Ebola Vaccines — NEJM Infectious diseases
The Bundibugyo virus outbreak in the DRC and Uganda has focused concern on potential countermeasures. Investigators assessed cross-reactive immune responses in serum obtained during previous Ebola vaccine trials.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Love and Death — NEJM Hematology-oncology
In the ICU, a resident is surrounded by deaths, each one leaving him with a sense of emptiness. Then a Christmas tragedy highlights medicine’s privilege of bearing witness to love as well as death.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract — NEJM Infectious diseases
In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infection, leading to a brain abscess.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Enfortumab Vedotin and Pembrolizumab in Cisplatin-Eligible Bladder Cancer — NEJM Hematology-oncology
Among cisplatin-eligible patients with muscle-invasive bladder cancer undergoing cystectomy, perioperative enfortumab vedotin–pembrolizumab led to significantly better event-free survival outcomes than cisplatin–gemcitabine.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Case 21-2026: A 28-Year-Old Man with Headache and Vision Loss in the Right Eye — NEJM Infectious diseases
A 28-year-old man was admitted to the hospital because of monocular vision loss. Examination showed optic disk edema, and imaging revealed liver lesions and lymphadenopathy. A diagnosis was made.Fonte: NEJM Infectious diseases — Categoria: medical_journals
The Best of Both Worlds — Using Clinical Trial and Observational Data to Evaluate Vaccine Protection — NEJM Health policy
Well-designed observational studies are critical to advancing understanding of the effects of vaccines. But they are often dismissed as lacking the methodologic rigor necessary to inform policymaking.Fonte: NEJM Health policy — Categoria: medical_journals
The Best of Both Worlds — Using Clinical Trial and Observational Data to Evaluate Vaccine Protection — NEJM Infectious diseases
Well-designed observational studies are critical to advancing understanding of the effects of vaccines. But they are often dismissed as lacking the methodologic rigor necessary to inform policymaking.Fonte: NEJM Infectious diseases — Categoria: medical_journals
National Elimination of Hepatitis C — The Case for Starting in Prisons and Jails — NEJM Health policy
The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system.Fonte: NEJM Health policy — Categoria: medical_journals
Neurocysticercosis — NEJM Infectious diseases
A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract — NEJM Genetics
In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infection, leading to a brain abscess.Fonte: NEJM Genetics — Categoria: medical_journals
National Elimination of Hepatitis C — The Case for Starting in Prisons and Jails — NEJM Infectious diseases
The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system.Fonte: NEJM Infectious diseases — Categoria: medical_journals
A New Standard in Muscle-Invasive Bladder Cancer — The End of the Cisplatin Era? — NEJM Hematology-oncology
For more than two decades, neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy has been the standard of care for muscle-invasive bladder cancer. Despite this approach, relapse rates have remained high and long-term survival gains have been modest. The treatment landscape began to shift with the NIAG…
National Elimination of Hepatitis C — The Case for Starting in Prisons and Jails — NEJM Gastroenterology
The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Case 21-2026: A 28-Year-Old Man with Headache and Vision Loss in the Right Eye — NEJM Clinical Medicine
A 28-year-old man was admitted to the hospital because of monocular vision loss. Examination showed optic disk edema, and imaging revealed liver lesions and lymphadenopathy. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Love and Death — NEJM Clinical Medicine
In the ICU, a resident is surrounded by deaths, each one leaving him with a sense of emptiness. Then a Christmas tragedy highlights medicine’s privilege of bearing witness to love as well as death.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Crew Resource Management — Navigating AI’s Automation Paradox — NEJM Clinical Medicine
The more capable an AI copilot appears, the more likely clinicians are to offload tasks to it, eroding skills required for detecting its errors. CRM can help overcome this “automation paradox.”Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Koebner Phenomenon from Wet Cupping — NEJM Clinical Medicine
A 35-year-old man with well-controlled plaque psoriasis presented with new skin lesions. Two weeks earlier, he had undergone wet cupping. Physical examination revealed erythematous, scaly papules and plaques on his back.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Koebner Phenomenon from Wet Cupping — NEJM Dermatology
A 35-year-old man with well-controlled plaque psoriasis presented with new skin lesions. Two weeks earlier, he had undergone wet cupping. Physical examination revealed erythematous, scaly papules and plaques on his back.Fonte: NEJM Dermatology — Categoria: medical_journals
When Celebrities Prescribe — Regulating Drug Promotion on the Internet — NEJM Endocrinology
Patient-targeted drug promotion has expanded beyond traditional advertising to the Internet, with social-media narratives shared by public figures. These new forms of marketing often evade regulatory scrutiny.Fonte: NEJM Endocrinology — Categoria: medical_journals
Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer — NEJM Gastroenterology
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy — NEJM Clinical Medicine
In this trial, among adolescents with obstructive hypertrophic cardiomyopathy, the cardiac myosin inhibitor mavacamten led to a significantly greater reduction in left ventricular outflow tract obstruction than placebo.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Neurocysticercosis — NEJM Clinical Medicine
A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Breaking the RAS Barrier in Pancreatic Cancer — NEJM Gastroenterology
For decades, pancreatic ductal adenocarcinoma (PDAC) has been perhaps the clearest example of a cancer that is driven by a dominant oncogenic event yet is resistant to therapeutic exploitation. More than 90% of pancreatic cancers harbor activating RAS mutations, most commonly those involving KRAS codon 12,...Fonte: NEJ…
Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy — NEJM Cardiology
In this trial, among adolescents with obstructive hypertrophic cardiomyopathy, the cardiac myosin inhibitor mavacamten led to a significantly greater reduction in left ventricular outflow tract obstruction than placebo.Fonte: NEJM Cardiology — Categoria: medical_journals
Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD — NEJM Cardiology
In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.Fonte: NEJM Cardiology — Categoria: medical_journals
Love and Death — NEJM Pulmonary-critical-care
In the ICU, a resident is surrounded by deaths, each one leaving him with a sense of emptiness. Then a Christmas tragedy highlights medicine’s privilege of bearing witness to love as well as death.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Neurocysticercosis — NEJM Neurology-neurosurgery
A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
When Celebrities Prescribe — Regulating Drug Promotion on the Internet — NEJM Health policy
Patient-targeted drug promotion has expanded beyond traditional advertising to the Internet, with social-media narratives shared by public figures. These new forms of marketing often evade regulatory scrutiny.Fonte: NEJM Health policy — Categoria: medical_journals
The Best of Both Worlds — Using Clinical Trial and Observational Data to Evaluate Vaccine Protection — NEJM Health policy
Well-designed observational studies are critical to advancing understanding of the effects of vaccines. But they are often dismissed as lacking the methodologic rigor necessary to inform policymaking.Fonte: NEJM Health policy — Categoria: medical_journals
Love and Death — NEJM Hematology-oncology
In the ICU, a resident is surrounded by deaths, each one leaving him with a sense of emptiness. Then a Christmas tragedy highlights medicine’s privilege of bearing witness to love as well as death.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
National Elimination of Hepatitis C — The Case for Starting in Prisons and Jails — NEJM Health policy
The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system.Fonte: NEJM Health policy — Categoria: medical_journals
Love and Death — NEJM Clinical Medicine
In the ICU, a resident is surrounded by deaths, each one leaving him with a sense of emptiness. Then a Christmas tragedy highlights medicine’s privilege of bearing witness to love as well as death.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Neurocysticercosis — NEJM Clinical Medicine
A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
National Elimination of Hepatitis C — The Case for Starting in Prisons and Jails — NEJM Infectious diseases
The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Neurocysticercosis — NEJM Infectious diseases
A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules.Fonte: NEJM Infectious diseases — Categoria: medical_journals
The Best of Both Worlds — Using Clinical Trial and Observational Data to Evaluate Vaccine Protection — NEJM Infectious diseases
Well-designed observational studies are critical to advancing understanding of the effects of vaccines. But they are often dismissed as lacking the methodologic rigor necessary to inform policymaking.Fonte: NEJM Infectious diseases — Categoria: medical_journals
When Celebrities Prescribe — Regulating Drug Promotion on the Internet — NEJM Endocrinology
Patient-targeted drug promotion has expanded beyond traditional advertising to the Internet, with social-media narratives shared by public figures. These new forms of marketing often evade regulatory scrutiny.Fonte: NEJM Endocrinology — Categoria: medical_journals
National Elimination of Hepatitis C — The Case for Starting in Prisons and Jails — NEJM Gastroenterology
The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system.Fonte: NEJM Gastroenterology — Categoria: medical_journals
Fibromyalgia — NEJM Rheumatology
Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended.Fonte: NEJM Rheumatology — Categoria: medical_journals
Descending Thoracic Aortic Aneurysm — NEJM Surgery
A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.Fonte: NEJM Surgery — Categoria: public_health
Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus — NEJM Rheumatology
In patients with SLE without advanced lupus nephritis, obinutuzumab plus standard therapy was superior to placebo plus standard therapy in conferring and sustaining a clinically meaningful reduction in disease activity over 52 weeks.Fonte: NEJM Rheumatology — Categoria: medical_journals
Targeted Degradation of NETs in Lupus with DNASE1L3 Deficiency — NEJM Rheumatology
Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach.Fonte: NEJM Rheumatology — Categoria: medical_journals
Pharmacotherapeutic Decisions in Autism — NEJM Neurology-neurosurgery
Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
The Symptom Tracker — NEJM Neurology-neurosurgery
As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Fibromyalgia — NEJM Neurology-neurosurgery
Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Fibromyalgia — NEJM Pediatrics
Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended.Fonte: NEJM Pediatrics — Categoria: medical_journals
Pharmacotherapeutic Decisions in Autism — NEJM Pediatrics
Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach.Fonte: NEJM Pediatrics — Categoria: medical_journals
Lead Lines in Severe Lead Poisoning — NEJM Pediatrics
A 6-month-old baby boy was transferred to a quaternary children’s hospital for seizures. A radiograph of a hand and wrist showed dense, transverse bands of metaphyseal sclerosis in the radius, ulna, metacarpals, and phalanges.Fonte: NEJM Pediatrics — Categoria: medical_journals
Large-Scale Premarital Genetic Screening in the United Arab Emirates — NEJM Obstetrics-gynecology
The authors describe the results of expanded premarital genetic screening, part of the Emirati Genome Program in the United Arab Emirates.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Fibromyalgia — NEJM Endocrinology
Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended.Fonte: NEJM Endocrinology — Categoria: medical_journals
Descending Thoracic Aortic Aneurysm — NEJM Emergency Medicine
A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Targeted Degradation of NETs in Lupus with DNASE1L3 Deficiency — NEJM Genetics
Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach.Fonte: NEJM Genetics — Categoria: medical_journals
Case 20-2026: A 38-Year-Old Man with Abdominal Pain — NEJM Gastroenterology
A 38-year-old man was evaluated at the hospital because of postprandial abdominal pain. Six weeks earlier, a diarrheal illness had developed while he was working in Madagascar. A diagnosis was made.Fonte: NEJM Gastroenterology — Categoria: medical_journals
The Symptom Tracker — NEJM Geriatrics-Aging
As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Large-Scale Premarital Genetic Screening in the United Arab Emirates — NEJM Genetics
The authors describe the results of expanded premarital genetic screening, part of the Emirati Genome Program in the United Arab Emirates.Fonte: NEJM Genetics — Categoria: medical_journals
Pharmacotherapeutic Decisions in Autism — NEJM Health policy
Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach.Fonte: NEJM Health policy — Categoria: medical_journals
Targeted Degradation of NETs in Lupus with DNASE1L3 Deficiency — NEJM Dermatology
Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach.Fonte: NEJM Dermatology — Categoria: medical_journals
Time to Stop? Rethinking the Duration of Maintenance Treatment in Multiple Myeloma — NEJM Hematology-oncology
Multiple myeloma has undergone a therapeutic revolution at a pace nearly unmatched in oncology. Yet amid these advances, a key assumption in multiple myeloma therapy persists: more and longer treatment is better. The trial by Kumar and colleagues (ENDURANCE), reported in this issue of the Journal,1 ...Fonte: NEJM Hemat…
Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma — NEJM Hematology-oncology
Among patients with multiple myeloma, 7-year overall survival with 2 years of lenalidomide therapy was similar to that with indefinite therapy. Adverse events and second cancers were more common with indefinite therapy.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Health Care–Associated Infections in U.S. Hospitals, 2023 versus 2015 — NEJM Infectious diseases
Health care–associated infections remain a major cause of illness across U.S. hospitals. In this cross-sectional study, the burden of such infections is compared between 2015 and 2023 with attention to changing definitions.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Bundibugyo Virus Disease in 2026 — Clinical and Public Health Responses — NEJM Infectious diseases
This review summarizes the current state of the 2026 filovirus disease outbreak in the Democratic Republic of Congo, as well as the principles and approaches that are informing the response.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Case 20-2026: A 38-Year-Old Man with Abdominal Pain — NEJM Infectious diseases
A 38-year-old man was evaluated at the hospital because of postprandial abdominal pain. Six weeks earlier, a diarrheal illness had developed while he was working in Madagascar. A diagnosis was made.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Lead Lines in Severe Lead Poisoning — NEJM Emergency Medicine
A 6-month-old baby boy was transferred to a quaternary children’s hospital for seizures. A radiograph of a hand and wrist showed dense, transverse bands of metaphyseal sclerosis in the radius, ulna, metacarpals, and phalanges.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
The Exam Room as Sanctuary — Caring for Undocumented Patients — NEJM Health policy
Caring for undocumented immigrants at a time of heightened fear requires actionable frameworks guided by compassion and respect. Trauma-informed care is a vital approach for physicians.Fonte: NEJM Health policy — Categoria: medical_journals
The Exam Room as Sanctuary — Caring for Undocumented Patients — NEJM Emergency Medicine
Caring for undocumented immigrants at a time of heightened fear requires actionable frameworks guided by compassion and respect. Trauma-informed care is a vital approach for physicians.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Andes Virus — A Clinical Review — NEJM Infectious diseases
Andes virus, the sole orthohantavirus with documented human-to-human transmission, causes hantavirus pulmonary syndrome (case fatality rate, 25 to 40%). Aggressive supportive care and strict infection-control measures are needed.Fonte: NEJM Infectious diseases — Categoria: medical_journals
A Regional Measles Outbreak — South Carolina, 2025–2026 — NEJM Infectious diseases
In South Carolina, 997 measles cases occurred in the reported outbreak. In one health care system, 81 cases were identified. Most were in unvaccinated persons; 13 persons were hospitalized, and 2 had measles encephalitis.Fonte: NEJM Infectious diseases — Categoria: medical_journals
The Symptom Tracker — NEJM Clinical Medicine
As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Case 20-2026: A 38-Year-Old Man with Abdominal Pain — NEJM Clinical Medicine
A 38-year-old man was evaluated at the hospital because of postprandial abdominal pain. Six weeks earlier, a diarrheal illness had developed while he was working in Madagascar. A diagnosis was made.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Targeted Degradation of NETs in Lupus with DNASE1L3 Deficiency — NEJM Allergy-Immunology
Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Lead Lines in Severe Lead Poisoning — NEJM Clinical Medicine
A 6-month-old baby boy was transferred to a quaternary children’s hospital for seizures. A radiograph of a hand and wrist showed dense, transverse bands of metaphyseal sclerosis in the radius, ulna, metacarpals, and phalanges.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Descending Thoracic Aortic Aneurysm — NEJM Clinical Medicine
A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Case 20-2026: A 38-Year-Old Man with Abdominal Pain — NEJM Allergy-Immunology
A 38-year-old man was evaluated at the hospital because of postprandial abdominal pain. Six weeks earlier, a diarrheal illness had developed while he was working in Madagascar. A diagnosis was made.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Balancing the Scales — Extended DAPT in Coronary Artery Disease — NEJM Cardiology
The appropriate duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) has remained the subject of a central debate in cardiovascular medicine. DAPT is intended to mitigate ischemic risk, but its maintenance warrants balancing the benefit against the concomitant risk of hemorrhage.1…
Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease — NEJM Cardiology
Among patients with multivessel coronary artery disease who were in stable condition 1 year after stenting, an additional year of DAPT led to a lower risk of ischemic events than aspirin alone, without increased bleeding.Fonte: NEJM Cardiology — Categoria: medical_journals
Health Care–Associated Infections in U.S. Hospitals, 2023 versus 2015 — NEJM Clinical Medicine
Health care–associated infections remain a major cause of illness across U.S. hospitals. In this cross-sectional study, the burden of such infections is compared between 2015 and 2023 with attention to changing definitions.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Descending Thoracic Aortic Aneurysm — NEJM Cardiology
A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.Fonte: NEJM Cardiology — Categoria: medical_journals
Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus — NEJM Clinical Medicine
In patients with SLE without advanced lupus nephritis, obinutuzumab plus standard therapy was superior to placebo plus standard therapy in conferring and sustaining a clinically meaningful reduction in disease activity over 52 weeks.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Fibromyalgia — NEJM Clinical Medicine
Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
The Exam Room as Sanctuary — Caring for Undocumented Patients — NEJM Clinical Medicine
Caring for undocumented immigrants at a time of heightened fear requires actionable frameworks guided by compassion and respect. Trauma-informed care is a vital approach for physicians.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Pharmacotherapeutic Decisions in Autism — NEJM Clinical Medicine
Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus — NEJM Allergy-Immunology
In patients with SLE without advanced lupus nephritis, obinutuzumab plus standard therapy was superior to placebo plus standard therapy in conferring and sustaining a clinically meaningful reduction in disease activity over 52 weeks.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Targeted Degradation of NETs in Lupus with DNASE1L3 Deficiency — NEJM Clinical Medicine
Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Pulmonary-critical-care
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Infectious diseases
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Hematology-oncology
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Allergy-Immunology
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Platelet-Activating Anti–Platelet Factor 4 Disorders — NEJM Cardiology
This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.Fonte: NEJM Cardiology — Categoria: medical_journals
Rivaroxaban Then Aspirin vs. Aspirin Alone after Total Hip or Knee Arthroplasty — NEJM Surgery
After total hip or knee arthroplasty, aspirin alone was noninferior to rivaroxaban followed by aspirin in preventing symptomatic venous thromboembolism, with a similarly low risk of bleeding complications.Fonte: NEJM Surgery — Categoria: public_health
Rivaroxaban Then Aspirin vs. Aspirin Alone after Total Hip or Knee Arthroplasty — NEJM Hematology-oncology
After total hip or knee arthroplasty, aspirin alone was noninferior to rivaroxaban followed by aspirin in preventing symptomatic venous thromboembolism, with a similarly low risk of bleeding complications.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Rivaroxaban Then Aspirin vs. Aspirin Alone after Total Hip or Knee Arthroplasty — NEJM Cardiology
After total hip or knee arthroplasty, aspirin alone was noninferior to rivaroxaban followed by aspirin in preventing symptomatic venous thromboembolism, with a similarly low risk of bleeding complications.Fonte: NEJM Cardiology — Categoria: medical_journals
Descending Thoracic Aortic Aneurysm — NEJM Surgery
A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.Fonte: NEJM Surgery — Categoria: public_health
Pharmacotherapeutic Decisions in Autism — NEJM Pediatrics
Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach.Fonte: NEJM Pediatrics — Categoria: medical_journals
Pharmacotherapeutic Decisions in Autism — NEJM Neurology-neurosurgery
Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
The Symptom Tracker — NEJM Neurology-neurosurgery
As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
The Symptom Tracker — NEJM Geriatrics-Aging
As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Pharmacotherapeutic Decisions in Autism — NEJM Health policy
Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach.Fonte: NEJM Health policy — Categoria: medical_journals
The Exam Room as Sanctuary — Caring for Undocumented Patients — NEJM Health policy
Caring for undocumented immigrants at a time of heightened fear requires actionable frameworks guided by compassion and respect. Trauma-informed care is a vital approach for physicians.Fonte: NEJM Health policy — Categoria: medical_journals
Pharmacotherapeutic Decisions in Autism — NEJM Clinical Medicine
Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Descending Thoracic Aortic Aneurysm — NEJM Cardiology
A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.Fonte: NEJM Cardiology — Categoria: medical_journals
The Symptom Tracker — NEJM Clinical Medicine
As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Descending Thoracic Aortic Aneurysm — NEJM Clinical Medicine
A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
The Exam Room as Sanctuary — Caring for Undocumented Patients — NEJM Clinical Medicine
Caring for undocumented immigrants at a time of heightened fear requires actionable frameworks guided by compassion and respect. Trauma-informed care is a vital approach for physicians.Fonte: NEJM Clinical Medicine — Categoria: medical_journals
Descending Thoracic Aortic Aneurysm — NEJM Emergency Medicine
A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
The Exam Room as Sanctuary — Caring for Undocumented Patients — NEJM Emergency Medicine
Caring for undocumented immigrants at a time of heightened fear requires actionable frameworks guided by compassion and respect. Trauma-informed care is a vital approach for physicians.Fonte: NEJM Emergency Medicine — Categoria: medical_journals
Long-Term Survival of Hypoimmune Allogeneic Islets without Immunosuppression — NEJM Hematology-oncology
A patient with type 1 diabetes received genetically modified allogeneic islets and no immunosuppression. Results obtained through 14 months support β-cell function and a lack of immune response against the allograft.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Long-Term Survival of Hypoimmune Allogeneic Islets without Immunosuppression — NEJM Genetics
A patient with type 1 diabetes received genetically modified allogeneic islets and no immunosuppression. Results obtained through 14 months support β-cell function and a lack of immune response against the allograft.Fonte: NEJM Genetics — Categoria: medical_journals
Long-Term Survival of Hypoimmune Allogeneic Islets without Immunosuppression — NEJM Endocrinology
A patient with type 1 diabetes received genetically modified allogeneic islets and no immunosuppression. Results obtained through 14 months support β-cell function and a lack of immune response against the allograft.Fonte: NEJM Endocrinology — Categoria: medical_journals
Long-Term Survival of Hypoimmune Allogeneic Islets without Immunosuppression — NEJM Allergy-Immunology
A patient with type 1 diabetes received genetically modified allogeneic islets and no immunosuppression. Results obtained through 14 months support β-cell function and a lack of immune response against the allograft.Fonte: NEJM Allergy-Immunology — Categoria: medical_journals
Phase 3 Trials of Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis — NEJM Pulmonary-critical-care
Among patients with idiopathic pulmonary fibrosis, inhaled treprostinil led to a smaller decline in forced vital capacity than placebo over 52 weeks. Cough and drug discontinuation were more common with treprostinil.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Nutrition Therapy in Critically Ill Adults — NEJM Pulmonary-critical-care
During the acute phase of critical illness, early restrictive-dose enteral nutrition is preferred over parenteral nutrition to support gut integrity. Full-dose enteral nutrition increases the risk of adverse effects.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Case 19-2026: A 68-Year-Old Man with Fatigue, Fever, and Hypoxemia — NEJM Pulmonary-critical-care
A 68-year-old man was evaluated in an outpatient clinic because of fatigue and dyspnea. Lung transplantation had been performed 15 months earlier. A diagnosis was made.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Preserving Lung Function in Idiopathic Pulmonary Fibrosis — NEJM Pulmonary-critical-care
Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease, with an estimated global yearly incidence of approximately 6 per 100,000 and a prevalence of approximately 18 per 100,000.1,2 Patients with IPF have progressive dyspnea that is commonly accompanied by a disabling cough, impaired quality o…
Case 19-2026: A 68-Year-Old Man with Fatigue, Fever, and Hypoxemia — NEJM Surgery
A 68-year-old man was evaluated in an outpatient clinic because of fatigue and dyspnea. Lung transplantation had been performed 15 months earlier. A diagnosis was made.Fonte: NEJM Surgery — Categoria: public_health
Contextualizing the Dead Donor Rule in an Era of Voluntary Euthanasia — NEJM Surgery
Growing acceptance of voluntary euthanasia, which opens the door to death by organ donation, warrants a recontextualization of the dead donor rule and assessment of the ethical principles involved.Fonte: NEJM Surgery — Categoria: public_health
Sparganosis — NEJM Surgery
A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier.Fonte: NEJM Surgery — Categoria: public_health
Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis — NEJM Pulmonary-critical-care
In a phase 3 trial involving patients with idiopathic pulmonary fibrosis, inhaled treprostinil was associated with a smaller decline in forced vital capacity and a lower risk of clinical worsening than placebo over 52 weeks.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Ensartinib in Resected ALK-Positive Non–Small-Cell Lung Cancer — NEJM Pulmonary-critical-care
Among patients with resected ALK-positive non–small-cell lung cancer, 2-year disease-free survival was higher with the ALK inhibitor ensartinib than with placebo. Grade 3 adverse events were more frequent with ensartinib.Fonte: NEJM Pulmonary-critical-care — Categoria: medical_journals
Mandated State-Level Surveillance of Assisted Reproductive Technology — An Emerging Threat in the United States — NEJM Obstetrics-gynecology
Proposed legislation in Arkansas outlines new guidelines for state surveillance of assisted reproductive technology and potentially lays the groundwork for personhood-based laws that could grant legal rights and protections to embryos.Fonte: NEJM Obstetrics-gynecology — Categoria: medical_journals
Setmelanotide for the Treatment of Acquired Hypothalamic Obesity — NEJM Pediatrics
Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks.Fonte: NEJM Pediatrics — Categoria: medical_journals
Science behind the Study: Treating Acquired Hypothalamic Obesity — NEJM Pediatrics
The author describes the scientific basis for a trial of an MC4R agonist in persons with acquired hypothalamic obesity. Those who received the drug had reductions in body-mass index and hunger.Fonte: NEJM Pediatrics — Categoria: medical_journals
The OMB and the Politicization of Science — NEJM Health policy
The Editors highlight three aspects of OMB’s recently proposed rule changes as particularly striking: that decisions on research funding would be made by political appointees, that funding could be cut off midway through a grant period, and that foreign interactions would be severely limited.Fonte: NEJM Health policy —…
Contextualizing the Dead Donor Rule in an Era of Voluntary Euthanasia — NEJM Health policy
Growing acceptance of voluntary euthanasia, which opens the door to death by organ donation, warrants a recontextualization of the dead donor rule and assessment of the ethical principles involved.Fonte: NEJM Health policy — Categoria: medical_journals
Mandated State-Level Surveillance of Assisted Reproductive Technology — An Emerging Threat in the United States — NEJM Health policy
Proposed legislation in Arkansas outlines new guidelines for state surveillance of assisted reproductive technology and potentially lays the groundwork for personhood-based laws that could grant legal rights and protections to embryos.Fonte: NEJM Health policy — Categoria: medical_journals
Ensartinib in Resected ALK-Positive Non–Small-Cell Lung Cancer — NEJM Hematology-oncology
Among patients with resected ALK-positive non–small-cell lung cancer, 2-year disease-free survival was higher with the ALK inhibitor ensartinib than with placebo. Grade 3 adverse events were more frequent with ensartinib.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
For Those Left Behind — NEJM Hematology-oncology
An ICU physician believed letting her father die at home meant comfort, dignity, control, family close by, and the quiet reassurance of hospice. But she didn’t realize what it would require of her family.Fonte: NEJM Hematology-oncology — Categoria: medical_journals
Colliding Forces — The Aging of the Baby Boom Generation and Contracting Nursing-Home Supply — NEJM Health policy
A rapid growth in the population of older Americans has long been anticipated. But projections didn’t anticipate that this transition would coincide with a sustained reduction in nursing-home services.Fonte: NEJM Health policy — Categoria: medical_journals
Sparganosis — NEJM Infectious diseases
A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Condyloma Acuminata of the Urethra — NEJM Infectious diseases
A 42-year-old man with a recent stem-cell transplant presented with a 2-week history of urinary frequency and weak stream. Papules were seen on the penile shaft. Urethroscopy showed papillomatous lesions on the urethral mucosa.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Measles Inclusion-Body Encephalitis after Allogeneic Stem-Cell Transplantation — NEJM Infectious diseases
A 21-year-old man had measles after allogeneic stem-cell transplantation complicated by graft-versus-host disease. After he had recovered from the acute infection, an encephalitis developed that was ultimately fatal.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection — NEJM Infectious diseases
Observational evidence suggests that the four-component meningococcal B vaccine (4CMenB) may reduce gonorrhea risk. In this randomized trial, 4CMenB did not result in a lower incidence of N. gonorrhoeae infection than placebo.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Trends and Prevalence of Chronic Kidney Disease in the United States — NEJM Nephrology
Updated estimates of the prevalence of CKD in the United States indicate that the overall national burden of CKD has remained stable, but an increasing proportion is associated with diabetes.Fonte: NEJM Nephrology — Categoria: medical_journals
Measles Inclusion-Body Encephalitis after Allogeneic Stem-Cell Transplantation — NEJM Neurology-neurosurgery
A 21-year-old man had measles after allogeneic stem-cell transplantation complicated by graft-versus-host disease. After he had recovered from the acute infection, an encephalitis developed that was ultimately fatal.Fonte: NEJM Neurology-neurosurgery — Categoria: medical_journals
Caring for an Aging America — The Looming Crisis of the Long-Term–Care Workforce — NEJM Health policy
The United States faces a projected shortage of millions of long-term–care workers by 2040. Yet in each area where progress could help address this gap, federal policy is moving in the wrong direction.Fonte: NEJM Health policy — Categoria: medical_journals
For Those Left Behind — NEJM Health policy
An ICU physician believed letting her father die at home meant comfort, dignity, control, family close by, and the quiet reassurance of hospice. But she didn’t realize what it would require of her family.Fonte: NEJM Health policy — Categoria: medical_journals
Case 19-2026: A 68-Year-Old Man with Fatigue, Fever, and Hypoxemia — NEJM Infectious diseases
A 68-year-old man was evaluated in an outpatient clinic because of fatigue and dyspnea. Lung transplantation had been performed 15 months earlier. A diagnosis was made.Fonte: NEJM Infectious diseases — Categoria: medical_journals
Contextualizing the Dead Donor Rule in an Era of Voluntary Euthanasia — NEJM Geriatrics-Aging
Growing acceptance of voluntary euthanasia, which opens the door to death by organ donation, warrants a recontextualization of the dead donor rule and assessment of the ethical principles involved.Fonte: NEJM Geriatrics-Aging — Categoria: medical_journals
Condyloma Acuminata of the Urethra — NEJM Hematology-oncology
A 42-year-old man with a recent stem-cell transplant presented with a 2-week history of urinary frequency and weak stream. Papules were seen on the penile shaft. Urethroscopy showed papillomatous lesions on the urethral mucosa.Fonte: NEJM Hematology-oncology — Categoria: medical_journals